PLA2G4A and CAP1

Number of citations of the paper that reports this interaction (PubMedID 18330356)
6

Data Source:
BioGRID (two hybrid)

		PLA2G4A	CAP1
Description		phospholipase A2 group IVA	cyclase associated actin cytoskeleton regulatory protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Cytoplasmic Vesicle	Extracellular Region Plasma Membrane Focal Adhesion Cortical Actin Cytoskeleton Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Actin Binding Adenylate Cyclase Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Arachidonic Acid Metabolic Process Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Regulation Of Cell Proliferation Icosanoid Biosynthetic Process Glycerophospholipid Catabolic Process Arachidonic Acid Secretion Cellular Response To Antibiotic	Cell Morphogenesis Ameboidal-type Cell Migration Receptor-mediated Endocytosis Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity Actin Polymerization Or Depolymerization Neutrophil Degranulation Regulation Of Adenylate Cyclase Activity
Pathways		phospho-PLA2 pathway Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA Arachidonic acid metabolism ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL COPI-independent Golgi-to-ER retrograde traffic	Platelet degranulation Role of ABL in ROBO-SLIT signaling Neutrophil degranulation
Drugs		Fluticasone propionate Quinacrine Niflumic Acid
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163) Generalized epilepsy ( 22949513) Hip circumference adjusted for BMI ( 28552196) Hyperinsulinemia in less-fat diet ( 30327367) Hyperinsulinemia x saturated fatty acids interaction ( 30327367) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798) Non-del(5q) myelodysplastic syndromes ( 31738830) Uterine fibroid size (maximum volume) ( 30196971) Zinc levels ( 26025379)
Interacting Genes		24 interacting genes: ANXA2 BORCS6 CAP1 CASP1 CASP3 CASP4 ITGA2B ITGB3 JAK1 KAT5 MAPK1 MAPK14 MAPKAPK5 MKNK1 NCF1 PLA2G5 PRKCA RELA RPS6KA5 SHBG SIRT2 UBXN1 VIM XAGE1B	9 interacting genes: ACTB ACTG1 BARD1 CAP2 LIG4 MYOC PLA2G4A SERPINB8 UCHL5
Entrez ID		5321	10487
HPRD ID		08986	09869
Ensembl ID		ENSG00000116711	ENSG00000131236
Uniprot IDs		B4DZI4 P47712	D3DPU2 Q01518
PDB IDs		1BCI 1CJY 1RLW	1K8F
Enriched GO Terms of Interacting Partners?
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