ATP6V1A and PPM1D

		ATP6V1A	PPM1D
Description		ATPase H+ transporting V1 subunit A	protein phosphatase, Mg2+/Mn2+ dependent 1D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Lysosomal Membrane Vacuolar Membrane Cytosol Plasma Membrane Microvillus Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome	Nucleus Nucleoplasm Cytosol
	Molecular Function	ATP Binding Proton-transporting ATPase Activity, Rotational Mechanism	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Cellular Response To Increased Oxygen Levels ATP Metabolic Process Phagosome Acidification Proton Transmembrane Transport	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Transcriptional regulation by RUNX2
Drugs		Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1
Diseases
GWAS		Prostate cancer ( 23535732)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		14 interacting genes: ANXA7 CD200R1L CDKN1A GCH1 GON4L KCNJ9 LPGAT1 LSAMP PPM1D RALGAPA1 SMN1 TK1 TMPRSS7 TUFM	25 interacting genes: ATP6V1A BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		523	8493
HPRD ID		06120	05482
Ensembl ID		ENSG00000114573	ENSG00000170836
Uniprot IDs		P38606	A0A0S2Z4M2 O15297
PDB IDs
Enriched GO Terms of Interacting Partners?
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