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PPM1D
Description
protein phosphatase, Mg2+/Mn2+ dependent 1D
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Serine/threonine Phosphatase Activity
Magnesium-dependent Protein Serine/threonine Phosphatase Activity
Protein Binding
Metal Ion Binding
Mitogen-activated Protein Kinase Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
DNA Methylation
Chromatin Silencing
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Protein Dephosphorylation
Negative Regulation Of Cell Proliferation
Cellular Response To Starvation
Response To Radiation
Response To Bacterium
DNA Damage Response, Signal Transduction By P53 Class Mediator
Peptidyl-threonine Dephosphorylation
Negative Regulation Of Gene Expression, Epigenetic
Pathways
Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS
Blood urea nitrogen levels (
31152163
)
Interacting Genes
25 interacting genes:
ATP6V1A
BEX2
CASZ1
CHEK2
DIRAS3
DKK3
EPSTI1
ERRFI1
GLCE
H3-3A
H3C1
ITIH5
KDM1A
LYPD3
MAPK11
MDM2
MRC2
NAT2
NCL
NSD3
OSGIN1
RHOBTB2
RPL5
TP53
UBC
Entrez ID
8493
HPRD ID
05482
Ensembl ID
ENSG00000170836
Uniprot IDs
A0A0S2Z4M2
O15297
PDB IDs
Enriched GO Terms of Interacting Partners
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