LSM8 and DBF4

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LSM8	DBF4
Description		LSM8 homolog, U6 small nuclear RNA associated	DBF4 zinc finger
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	MRNA Splicing, Via Spliceosome RNA Metabolic Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition
Pathways		mRNA Splicing - Major Pathway	Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Triglyceride levels ( 30108155)	Metabolite levels ( 23823483)
Interacting Genes		49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1	18 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6
Entrez ID		51691	10926
HPRD ID		06288	10371
Ensembl ID		ENSG00000128534	ENSG00000006634
Uniprot IDs		A4D0W0 O95777	B4DXK0 B7Z8C6 Q9UBU7
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	4F99 4F9A 4F9B 4F9C
Enriched GO Terms of Interacting Partners?
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