PDK2 and PDHA1

Number of citations of the paper that reports this interaction (PubMedID 12676647)
138

Data Source:
HPRD (in vitro)

		PDK2	PDHA1
Description		pyruvate dehydrogenase kinase 2	pyruvate dehydrogenase E1 subunit alpha 1
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Pyruvate Dehydrogenase Complex	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity ATP Binding Protein Homodimerization Activity	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity
	Biological Process	Glucose Metabolic Process Regulation Of Gluconeogenesis Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Reactive Oxygen Species Glucose Homeostasis Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Pyruvate Dehydrogenase Activity	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs		4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (N-{4-[(ETHYLANILINO)SULFONYL]-2-METHYLPHENYL}-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE	NADH
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS			Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: AKT1 DLAT HIC2 HTT ISOC2 PDHA1 PDHX PDK1 SGK1 VSIG4	9 interacting genes: DLAT EIF6 HSD17B10 PDHB PDK1 PDK2 PDK3 PDK4 PDP1
Entrez ID		5164	5160
HPRD ID		03955	02420
Ensembl ID		ENSG00000005882	ENSG00000131828
Uniprot IDs		Q15119	A0A024RBX9 P08559
PDB IDs		2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8 4MP2 4MP7 4MPC 4MPE 4MPN 4V25 4V26 5J6A 5J71 5M4K 5M4M 5M4N 5M4P	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?
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