PDK2 and DLAT

Number of citations of the paper that reports this interaction (PubMedID 11978179)
19

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		PDK2	DLAT
Description		pyruvate dehydrogenase kinase 2	dihydrolipoamide S-acetyltransferase
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Pyruvate Dehydrogenase Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity ATP Binding Protein Homodimerization Activity	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Identical Protein Binding
	Biological Process	Glucose Metabolic Process Regulation Of Gluconeogenesis Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Reactive Oxygen Species Glucose Homeostasis Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Pyruvate Dehydrogenase Activity	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Sleep
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs		4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (N-{4-[(ETHYLANILINO)SULFONYL]-2-METHYLPHENYL}-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE	NADH Radicicol Dihydrolipoic Acid
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS
Interacting Genes		10 interacting genes: AKT1 DLAT HIC2 HTT ISOC2 PDHA1 PDHX PDK1 SGK1 VSIG4	7 interacting genes: PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3
Entrez ID		5164	1737
HPRD ID		03955	10578
Ensembl ID		ENSG00000005882	ENSG00000150768
Uniprot IDs		Q15119	P10515 Q86YI5
PDB IDs		2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8 4MP2 4MP7 4MPC 4MPE 4MPN 4V25 4V26 5J6A 5J71 5M4K 5M4M 5M4N 5M4P	1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55
Enriched GO Terms of Interacting Partners?
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