PDHA1 and PDK1

Number of citations of the paper that reports this interaction (PubMedID 12676647)
138

Data Source:
HPRD (in vitro)

		PDHA1	PDK1
Description		pyruvate dehydrogenase E1 subunit alpha 1	pyruvate dehydrogenase kinase 1
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GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate	Glucose Metabolic Process Protein Phosphorylation Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Glucose Homeostasis Hypoxia-inducible Factor-1alpha Signaling Pathway Negative Regulation Of Pyruvate Dehydrogenase Activity
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		NADH	4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE Dichloroacetic Acid
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Metabolite levels ( 23823483)	Blood protein levels ( 28240269) Erectile dysfunction in type 1 diabetes ( 22704111) Fasting plasma glucose ( 25187374)
Interacting Genes		9 interacting genes: DLAT EIF6 HSD17B10 PDHB PDK1 PDK2 PDK3 PDK4 PDP1	15 interacting genes: AKT1 COL6A1 DLAT FGFR1 ITGB3 KAT2B LAMTOR5 PDHA1 PDK2 PIK3CA RPS6KB1 SGK1 USP4 XRCC6 YWHAQ
Entrez ID		5160	5163
HPRD ID		02420	03954
Ensembl ID		ENSG00000131828	ENSG00000152256
Uniprot IDs		A0A024RBX9 P08559	B7Z7N6 Q15118
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO	2Q8F 2Q8G 2Q8H
Enriched GO Terms of Interacting Partners?
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