PDE1B and PRIM1

		PDE1B	PRIM1
Description		phosphodiesterase 1B	DNA primase subunit 1
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GO Annotations	Cellular Component	Cytosol Neuronal Cell Body	Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane
	Molecular Function	3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-dependent Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Calmodulin Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity Calcium- And Calmodulin-regulated 3',5'-cyclic-GMP Phosphodiesterase Activity	Single-stranded DNA Binding DNA Primase Activity Protein Binding Metal Ion Binding
	Biological Process	Response To Amphetamine Apoptotic Process G Protein-coupled Receptor Signaling Pathway Locomotory Behavior Visual Learning Monocyte Differentiation Cellular Response To Macrophage Colony-stimulating Factor Stimulus Regulation Of Dopamine Metabolic Process Serotonin Metabolic Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus	G1/S Transition Of Mitotic Cell Cycle DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways		Cam-PDE 1 activation cGMP effects G alpha (s) signalling events	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Caffeine Nicardipine Felodipine Bepridil S,S-(2-Hydroxyethyl)Thiocysteine Trapidil
Diseases
GWAS		Post bronchodilator FEV1 in COPD ( 26634245)	Asthma ( 31619474) Height ( 31562340) Mean corpuscular volume ( 27863252) Menopause (age at onset) ( 22267201 26414677) Plateletcrit ( 27863252) Red blood cell count ( 29403010)
Interacting Genes		3 interacting genes: POT1 PRIM1 UBE3A	14 interacting genes: MDC1 MRPL38 NFE2 PDE1B PRIM2 RAB5B RARG RPS26 SENP1 SLC11A2 SLC26A8 STAT6 TP53 YIF1A
Entrez ID		5153	5557
HPRD ID		01388	08899
Ensembl ID		ENSG00000123360	ENSG00000198056
Uniprot IDs		A0A024RB59 B3KX78 B4DK72 Q01064 Q7Z364	P49642
PDB IDs		1LXR 1TAZ 4NPV 4NPW 5B25 5UOY 5UP0 5W6E	4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4
Enriched GO Terms of Interacting Partners?
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