PDE6G and L3MBTL3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PDE6G	L3MBTL3
Description		phosphodiesterase 6G	L3MBTL histone methyl-lysine binding protein 3
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GO Annotations	Cellular Component	Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane	Nucleoplasm Nucleolus
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Spectrin Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Molecular_function DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Activation Of MAPK Activity Wnt Signaling Pathway, Calcium Modulating Pathway Visual Perception Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway	Chromatin Organization Regulation Of Transcription, DNA-templated Macrophage Differentiation Granulocyte Differentiation Erythrocyte Maturation
Pathways		Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway
Drugs		Sildenafil Vardenafil 3-isobutyl-1-methyl-7H-xanthine
Diseases		Retinitis pigmentosa (RP)
GWAS		Blond vs. brown/black hair color ( 30531825)	Birth weight ( 31043758 27680694) Body mass index ( 25673413) Breast cancer ( 29059683 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) C-reactive protein levels ( 30388399) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951) Hematocrit ( 27863252) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 25673412) Influenza A (H1N1) infection ( 26379185) Lymphocyte counts ( 27863252) Mild influenza (H1N1) infection ( 26379185) Multiple sclerosis ( 31604244 27386562) Offspring birth weight ( 31043758) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Weight ( 28552196)
Interacting Genes		11 interacting genes: BHLHE40 DNM2 FNBP1 GNAO1 GRB2 GRK2 L3MBTL3 MAPK3 SLC27A2 SRC TRIP10	30 interacting genes: ASB6 BANP BYSL DNMT1 KDM1A LRRK2 LSM4 LZTR1 MAPK3 MAPK9 MORF4L1 MORF4L2 NGB OAZ3 PDE6G PHC2 PIK3R3 PLEKHF1 PLEKHF2 POLR2L PRKAA1 PRKAA2 SNRPB SOX2 SP100 SUMO1P1 THRA TSTD2 TTC19 ZCWPW1
Entrez ID		5148	84456
HPRD ID		08914	11222
Ensembl ID		ENSG00000185527	ENSG00000198945
Uniprot IDs		P18545	Q96JM7
PDB IDs		3JWR	1WJQ 1WJS 3UT1 4FL6 4L59
Enriched GO Terms of Interacting Partners?
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