EVL and SPTA1

Number of citations of the paper that reports this interaction (PubMedID 16336193)
11

Data Source:
HPRD (two hybrid)

		EVL	SPTA1
Description		Enah/Vasp-like	spectrin alpha, erythrocytic 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium Phagocytic Vesicle	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Axon Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Actin Filament Binding
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Cellular Response To Interferon-gamma Negative Regulation Of Ruffle Assembly	MAPK Cascade Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process ER To Golgi Vesicle-mediated Transport Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases			Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)
GWAS		Blood protein levels ( 30072576) White matter hyperintensity burden ( 25663218)	Glycated hemoglobin levels ( 20858683 28898252) Hemoglobin A1c levels ( 29844224) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Lymphocyte counts ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Neutrophil percentage of white cells ( 27863252) Night sleep phenotypes ( 27126917) Other erythrocyte phenotypes ( 19862010) QRS duration ( 27577874) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		30 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP ENAH FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17	15 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 ENAH EVL FANCC FASLG PLEC SLC9A2 SPTB SPTBN2 VASP YWHAQ
Entrez ID		51466	6708
HPRD ID		10942	01685
Ensembl ID		ENSG00000196405	ENSG00000163554
Uniprot IDs		A0A024R6K5 Q9UI08	P02549
PDB IDs			1OWA 3LBX 5J4O
Enriched GO Terms of Interacting Partners?
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