SPTA1 and SPTBN2

Number of citations of the paper that reports this interaction (PubMedID 10852813)
89

Data Source:
HPRD (in vivo)

		SPTA1	SPTBN2
Description		spectrin alpha, erythrocytic 1	spectrin beta, non-erythrocytic 2
Image
GO Annotations	Cellular Component	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Axon Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate	Extracellular Space Cytosol Spectrin Apical Plasma Membrane Cell Junction Neuronal Cell Body Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse Postsynaptic Spectrin-associated Cytoskeleton
	Molecular Function	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Actin Filament Binding	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding Cadherin Binding Structural Constituent Of Synapse
	Biological Process	MAPK Cascade Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process ER To Golgi Vesicle-mediated Transport Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping	MAPK Cascade ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Synapse Assembly Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellar Purkinje Cell Layer Morphogenesis Adult Behavior Multicellular Organism Growth Actin Filament Capping Postsynapse Organization
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Glycated hemoglobin levels ( 20858683 28898252) Hemoglobin A1c levels ( 29844224) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Lymphocyte counts ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Neutrophil percentage of white cells ( 27863252) Night sleep phenotypes ( 27126917) Other erythrocyte phenotypes ( 19862010) QRS duration ( 27577874) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Bipolar disorder ( 28115744 21926972 31043756)
Interacting Genes		15 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 ENAH EVL FANCC FASLG PLEC SLC9A2 SPTB SPTBN2 VASP YWHAQ	10 interacting genes: ACTA1 ACTB ACTR1A APC CELSR3 DCTN1 MINK1 SPTA1 SPTAN1 UNC13B
Entrez ID		6708	6712
HPRD ID		01685	05404
Ensembl ID		ENSG00000163554	ENSG00000173898
Uniprot IDs		P02549	O15020
PDB IDs		1OWA 3LBX 5J4O	1WJM 1WYQ 6ANU
Enriched GO Terms of Interacting Partners?
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