GOLM1 and SLC40A1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		GOLM1	SLC40A1
Description		golgi membrane protein 1	solute carrier family 40 member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Integral Component Of Plasma Membrane	Cell Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Protein Binding	Iron Ion Transmembrane Transporter Activity Protein Binding Ferrous Iron Transmembrane Transporter Activity Peptide Hormone Binding Identical Protein Binding
	Biological Process	Nucleus Organization Regulation Of Lipid Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process	Lymphocyte Homeostasis Endothelium Development Cellular Iron Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Iron Ion Transmembrane Transport Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Iron Ion Homeostasis Spleen Trabecula Formation Multicellular Organismal Iron Ion Homeostasis Divalent Inorganic Cation Transport Ferrous Iron Export Across Plasma Membrane
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Iron uptake and transport
Drugs
Diseases			Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Blood protein levels ( 30072576) Logical memory (delayed recall) in normal cognition ( 29274321)	Bone fracture in osteoporosis ( 28580392) Iron status biomarkers (ferritin levels) ( 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Red blood cell count ( 27863252)
Interacting Genes		27 interacting genes: B3GNT4 C1orf174 CIAO1 CLK1 DCK DCTN2 DEXI EFTUD2 EIF2B3 EIF3J ELAC2 FLOT1 FTH1 GEMIN7 GRIK5 KCNE3 LSM12 MED22 NIPSNAP3A NRSN2 RACK1 RPA2 RPL13A SLC40A1 SYT1 TLE1 ZFAND3	2 interacting genes: GOLM1 HAMP
Entrez ID		51280	30061
HPRD ID		08428	05229
Ensembl ID		ENSG00000135052	ENSG00000138449
Uniprot IDs		B3KNK9 Q8NBJ4	Q9NP59
PDB IDs
Enriched GO Terms of Interacting Partners?
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