RLIM and LDB1

Number of citations of the paper that reports this interaction (PubMedID 11882901)
59

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RLIM	LDB1
Description		ring finger protein, LIM domain interacting	LIM domain binding 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Transcriptional Repressor Complex	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cell Leading Edge Protein-containing Complex Beta-catenin-TCF Complex
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Activating Transcription Factor Binding Transcription Corepressor Activity Protein Binding Enzyme Binding LIM Domain Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Random Inactivation Of X Chromosome Regulation Of Dosage Compensation By Inactivation Of X Chromosome	Negative Regulation Of Transcription By RNA Polymerase II Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organism Development Neuron Differentiation Regulation Of Cell Migration Regulation Of DNA-templated Transcription, Elongation Regulation Of Kinase Activity Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Regulation Of Focal Adhesion Assembly Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS			General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Pulse pressure ( 30578418)
Interacting Genes		30 interacting genes: BRF1 ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LNX2 MDM2 PDLIM1 REXO1 RPS14 SIN3A SMAD7 SMURF2 SNX17 SS18L1 STAT6 TERF1 TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2K	27 interacting genes: ATXN1 CTDSP1 DNMT3L ESR1 IRAK3 ISL1 LHX2 LHX3 LHX8 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP UPF1
Entrez ID		51132	8861
HPRD ID		02304	09144
Ensembl ID		ENSG00000131263	ENSG00000198728
Uniprot IDs		Q9NVW2	Q86U70
PDB IDs			2XJY 2XJZ 2YPA
Enriched GO Terms of Interacting Partners?
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