MRPL4 and ECSIT

		MRPL4	ECSIT
Description		mitochondrial ribosomal protein L4	ECSIT signaling integrator
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Protein Binding
	Biological Process	Mitochondrial Translational Elongation Mitochondrial Translational Termination	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Alanine transaminase levels ( 29403010) Pulse pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		9 interacting genes: CLK2 CSNK2A1 DDX24 ECSIT EIF2B1 EXOSC6 KRTAP4-12 TRIM23 XRN2	50 interacting genes: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CNN1 CORO2B CYP2C18 CYP2C8 CYP2C9 DNAJB1 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MARCHF2 MAST1 MRPL4 NDUFA13 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59
Entrez ID		51073	51295
HPRD ID		14759	12225
Ensembl ID		ENSG00000105364	ENSG00000130159
Uniprot IDs		A0A024R7C5 Q9BYD3 X6RAY8	Q9BQ95
PDB IDs		3J7Y 3J9M 5OOL 5OOM 6NU2 6NU3
Enriched GO Terms of Interacting Partners?
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