PAX6 and SHANK3

  • Number of citations of the paper that reports this interaction (PubMedID 16637659)
  • 25
  • Data Source:
  • HPRD (in vitro)

PAX6

SHANK3

Description paired box 6 SH3 and multiple ankyrin repeat domains 3
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Body mass index ( 22344219 28892062)
  • Depression ( 29700475)
  • Diastolic blood pressure ( 27841878)
  • Feeling worry ( 29500382)
  • General factor of neuroticism ( 30867560)
  • Irritable mood ( 29500382)
  • Major depressive disorder ( 27479909)
  • Neurociticism ( 29500382)
  • Optic disc area ( 28073927)
  • Systolic blood pressure ( 27841878)
  • Blood protein levels ( 30072576)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Extremely high intelligence ( 29520040)
  • Fibrinogen ( 23969696)
  • Fibrinogen levels ( 28107422 26561523)
  • Intelligence (MTAG) ( 29326435)
  • Memory dysfunction in frontotemporal lobe dementia ( 29724592)
Interacting Genes 32 interacting genes: CDX2 DIAPH1 DLG1 DYNLL1 EN1 EP300 HIPK2 HOMER3 HOXB1 IPO13 LHX2 MAFG MID1 MITF NKIRAS2 PATJ PBX1 PKNOX1 PROX1 RAX RB1 RGS3 SHANK3 SIX3 SMARCA4 SOX10 SOX3 SUMO1 TBP TRIM11 UBE3A VSX2 17 interacting genes: ABCC2 CNKSR2 COPS5 CRKL CSNK2B DLGAP1 DLGAP2 DLGAP3 DLGAP4 GRB2 MAPK1 NCK1 PAX6 PPP1CC RPS6KA1 SPTAN1 USP8
Entrez ID 5080 85358
HPRD ID 06167 18979
Ensembl ID ENSG00000007372 ENSG00000251322
Uniprot IDs A0A1W2PRA8 D1KF47 F1T0F8 P26367 Q66SS1
PDB IDs 2CUE 6PAX
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?