PAM and TSC2

Number of citations of the paper that reports this interaction (PubMedID 14559897)
35

Data Source:
HPRD (in vitro)

		PAM	TSC2
Description		peptidylglycine alpha-amidating monooxygenase	TSC complex subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Trans-Golgi Network Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Transport Vesicle Membrane Secretory Granule Membrane Neuron Projection Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Cytoplasm Lysosome Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Peptidylglycine Monooxygenase Activity Peptidylamidoglycolate Lyase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Protein Kinase Binding L-ascorbic Acid Binding Identical Protein Binding	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Peptide Amidation Response To Hypoxia Long-chain Fatty Acid Metabolic Process Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Heart Development Lactation Response To PH Toxin Metabolic Process Response To Zinc Ion Protein Amidation Ovulation Cycle Process Response To Estradiol Regulation Of Actin Cytoskeleton Organization Odontogenesis Response To Drug Response To Copper Ion Regulation Of Protein Secretion Response To Glucocorticoid Oxidation-reduction Process Maternal Process Involved In Female Pregnancy Limb Development	Neural Tube Closure Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Endocytosis Heart Development Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of TOR Signaling Anoikis Protein Kinase B Signaling Positive Regulation Of GTPase Activity Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Mitophagy
Pathways			Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs
Drugs		Vitamin C N-Alpha-Acetyl-3,5-Diiodotyrosylglycine Threonine Derivative
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Blood protein levels ( 30072576 29875488) Diastolic blood pressure ( 29208002) Early cardiac repolarization ( 31600170) Feeling worry ( 29500382) Insulinogenic index ( 23263489) Medication use (drugs used in diabetes) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033) Primary biliary cholangitis ( 26394269) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 29208002) Type 2 diabetes ( 30054458 29358691 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)	Major depressive disorder ( 29317602) Obesity-related traits ( 23251661)
Interacting Genes		10 interacting genes: CALM1 FXYD1 GLP1R KALRN POMC PRKCA RASSF9 TBCA TSC2 UHMK1	42 interacting genes: AKT1 AKT2 AKT3 CALM1 CBY2 CCND1 CDKN1B ESR1 FBXL6 FBXW5 GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI NEK1 PAM PIN1 PLK2 PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPS6KA1 SFN SMAD2 SMAD3 SUPT6H TK1 TSC1 UBE3A YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		5066	7249
HPRD ID		01361	01850
Ensembl ID		ENSG00000145730	ENSG00000103197
Uniprot IDs		O43832 P19021	B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D7Q2
PDB IDs
Enriched GO Terms of Interacting Partners?
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