PAM and FXYD1

Number of citations of the paper that reports this interaction (PubMedID 18052119)
57

Data Source:
HPRD (in vivo)

		PAM	FXYD1
Description		peptidylglycine alpha-amidating monooxygenase	FXYD domain containing ion transport regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Trans-Golgi Network Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Transport Vesicle Membrane Secretory Granule Membrane Neuron Projection Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Apical Plasma Membrane T-tubule Sarcolemma
	Molecular Function	Peptidylglycine Monooxygenase Activity Peptidylamidoglycolate Lyase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Protein Kinase Binding L-ascorbic Acid Binding Identical Protein Binding	Chloride Channel Activity Sodium Channel Regulator Activity Ion Channel Binding Ion Channel Regulator Activity
	Biological Process	Peptide Amidation Response To Hypoxia Long-chain Fatty Acid Metabolic Process Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Heart Development Lactation Response To PH Toxin Metabolic Process Response To Zinc Ion Protein Amidation Ovulation Cycle Process Response To Estradiol Regulation Of Actin Cytoskeleton Organization Odontogenesis Response To Drug Response To Copper Ion Regulation Of Protein Secretion Response To Glucocorticoid Oxidation-reduction Process Maternal Process Involved In Female Pregnancy Limb Development	Potassium Ion Transport Sodium Ion Transport Chloride Transport Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Protein Glutathionylation Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Ion homeostasis Ion transport by P-type ATPases
Drugs		Vitamin C N-Alpha-Acetyl-3,5-Diiodotyrosylglycine Threonine Derivative
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Diastolic blood pressure ( 29208002) Early cardiac repolarization ( 31600170) Feeling worry ( 29500382) Insulinogenic index ( 23263489) Medication use (drugs used in diabetes) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033) Primary biliary cholangitis ( 26394269) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 29208002) Type 2 diabetes ( 30054458 29358691 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		10 interacting genes: CALM1 FXYD1 GLP1R KALRN POMC PRKCA RASSF9 TBCA TSC2 UHMK1	8 interacting genes: ATP1A1 ATP1B1 DMPK PAM PLPP1 PPP1CA PRKACA YWHAQ
Entrez ID		5066	5348
HPRD ID		01361	03837
Ensembl ID		ENSG00000145730	ENSG00000266964
Uniprot IDs		O43832 P19021	O00168
PDB IDs			2J1I 2JO1
Enriched GO Terms of Interacting Partners?
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