PCSK6 and IL16

		PCSK6	IL16
Description		proprotein convertase subtilisin/kexin type 6	interleukin 16
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Membrane Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Cytosol Plasma Membrane Nuclear Speck Flemming Body
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Nerve Growth Factor Binding	Cytokine Activity CD4 Receptor Binding
	Biological Process	Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Processing Nerve Growth Factor Production Secretion By Cell Regulation Of Lipoprotein Lipase Activity Cornification	Immune Response Viral Process Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Induction Of Positive Chemotaxis Regulation Of Calcium Ion Transport
Pathways		Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes	Other interleukin signaling
Drugs
Diseases
GWAS		Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Platelet-derived growth factor BB levels ( 27989323) Relative hand skill in reading disability ( 24068947) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)	Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Brown vs. black hair color ( 30531825) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Height ( 31562340) Inattentive symptoms ( 18821565) Interleukin-16 levels ( 27989323) Primary biliary cholangitis ( 28425483)
Interacting Genes		10 interacting genes: ALPL CACNA1A FLG FN3K IGF1R IL16 PMCH RCN3 SNRPA1 SYNM	31 interacting genes: CASP3 CD4 CDK1 CSNK2A1 CSNK2A2 DMRTB1 EFEMP2 GABPB1 GRIN2A GRIN2B GRIN2C GRIN2D HDAC3 KCNA3 KCND1 KCND2 KCNJ10 KCNJ15 KCNJ2 KCNJ4 KDM1A LNX2 PCSK6 PPP1R12A PPP1R12B PPP1R12C SUV39H1 TFIP11 TRIP6 USHBP1 ZNRD2
Entrez ID		5046	3603
HPRD ID		01329	04329
Ensembl ID		ENSG00000140479	ENSG00000172349
Uniprot IDs		A2RQD9 H7BXT3 P29122 Q59H04	Q14005 Q9UME6
PDB IDs			1I16 1X6D 5FB8
Enriched GO Terms of Interacting Partners?
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