ORC1 and CDT1

Number of citations of the paper that reports this interaction (PubMedID 15232106)
123

Data Source:
HPRD (in vitro)

		ORC1	CDT1
Description		origin recognition complex subunit 1	chromatin licensing and DNA replication factor 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol	Kinetochore Condensed Chromosome Kinetochore Cell Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	DNA Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation Mitotic DNA Replication Checkpoint	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Chromosome Segregation Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of Protein Complex Assembly Regulation Of Chromosome Organization Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization DNA Replication Preinitiation Complex Assembly Response To Sorbitol Deactivation Of Mitotic Spindle Assembly Checkpoint Regulation Of DNA Replication Origin Binding Negative Regulation Of Protein Localization To Kinetochore Positive Regulation Of Protein Localization To Kinetochore Positive Regulation Of DNA-dependent DNA Replication
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription	CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome	Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS			Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978 28017375) Mean corpuscular volume ( 29403010)
Interacting Genes		23 interacting genes: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RB1 RPA2 SKP2 TMEM97 XPO1	28 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM2 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB
Entrez ID		4998	81620
HPRD ID		03544	06900
Ensembl ID		ENSG00000085840	ENSG00000167513
Uniprot IDs		B7Z8H0 Q13415 Q96F82	Q9H211
PDB IDs		5UJ7 5UJM 6P3W	2LE8 2WVR 6QCG
Enriched GO Terms of Interacting Partners?
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