ORC1 and TMEM97

		ORC1	TMEM97
Description		origin recognition complex subunit 1	transmembrane protein 97
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol	Lysosome Endoplasmic Reticulum Rough Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Rough Endoplasmic Reticulum Membrane Nuclear Membrane
	Molecular Function	DNA Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Metal Ion Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation Mitotic DNA Replication Checkpoint	Regulation Of Cell Growth Cholesterol Homeostasis
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS			Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 29875488) Osteoprotegerin levels ( 25080503)
Interacting Genes		23 interacting genes: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RB1 RPA2 SKP2 TMEM97 XPO1	10 interacting genes: ADCYAP1R1 APP CRLF3 ERAL1 ORC1 POLDIP2 RNF167 TADA1 TBC1D29P UTP4
Entrez ID		4998	27346
HPRD ID		03544	14343
Ensembl ID		ENSG00000085840	ENSG00000109084
Uniprot IDs		B7Z8H0 Q13415 Q96F82	Q5BJF2
PDB IDs		5UJ7 5UJM 6P3W
Enriched GO Terms of Interacting Partners?
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