CDT1 and FBXO31

Number of citations of the paper that reports this interaction (PubMedID 24828503)
19

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)

		CDT1	FBXO31
Description		chromatin licensing and DNA replication factor 1	F-box protein 31
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Cell Nucleus Nucleoplasm Cytosol Nuclear Body	Centrosome Cytosol SCF Ubiquitin Ligase Complex Neuronal Cell Body
	Molecular Function	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding	Protein Binding Cyclin Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Chromosome Segregation Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of Protein Complex Assembly Regulation Of Chromosome Organization Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization DNA Replication Preinitiation Complex Assembly Response To Sorbitol Deactivation Of Mitotic Spindle Assembly Checkpoint Regulation Of DNA Replication Origin Binding Negative Regulation Of Protein Localization To Kinetochore Positive Regulation Of Protein Localization To Kinetochore Positive Regulation Of DNA-dependent DNA Replication	Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Post-translational Protein Modification Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Neuron Migration
Pathways		CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978 28017375) Mean corpuscular volume ( 29403010)	Experiencing mood swings ( 29500382) Feeling nervous ( 29500382) Major depressive disorder ( 22472876) Neurociticism ( 29500382) Neuroticism ( 29255261)
Interacting Genes		28 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM2 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB	5 interacting genes: AKT1 CCND1 CDT1 GHR MDM2
Entrez ID		81620	79791
HPRD ID		06900	10954
Ensembl ID		ENSG00000167513	ENSG00000103264
Uniprot IDs		Q9H211	A0A0C4DGU8 Q5XUX0
PDB IDs		2LE8 2WVR 6QCG	5VZT 5VZU
Enriched GO Terms of Interacting Partners?
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