NT5E and ATP6AP1

		NT5E	ATP6AP1
Description		5'-nucleotidase ecto	ATPase H+ transporting accessory protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Exosome	Cell Endoplasmic Reticulum Membrane Endosome Membrane Integral Component Of Membrane Proton-transporting Two-sector ATPase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Proton-transporting V-type ATPase, V1 Domain Plasma Membrane Proton-transporting V-type ATPase Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding 5'-nucleotidase Activity Metal Ion Binding	Protein Binding ATP Binding Rab GTPase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Purine Nucleotide Catabolic Process AMP Catabolic Process DNA Metabolic Process Leukocyte Cell-cell Adhesion Dephosphorylation NAD Metabolic Process Adenosine Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Negative Regulation Of Inflammatory Response	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway Regulation Of Cellular PH Transferrin Transport Ion Transmembrane Transport Cellular Response To Increased Oxygen Levels Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Resorption PH Reduction Positive Regulation Of Exocytosis Establishment Of Organelle Localization Positive Regulation Of ERK1 And ERK2 Cascade Proton Transmembrane Transport Positive Regulation Of Osteoclast Development
Pathways		Nicotinate metabolism Pyrimidine catabolism Purine catabolism Purinergic signaling in leishmaniasis infection	Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport
Drugs		Pentoxifylline
Diseases		Calcification of joints and arteries
GWAS		Blood metabolite levels ( 24816252) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolic traits ( 21886157)
Interacting Genes		5 interacting genes: ACTB AFF1 ATP6AP1 FN1 LAMA1	11 interacting genes: ABCD1 ANG CETN2 CTAG1B ERBB2 HBA1 LARP1 NR1I2 NT5E RHOU SYVN1
Entrez ID		4907	537
HPRD ID		00552	02184
Ensembl ID		ENSG00000135318	ENSG00000071553
Uniprot IDs		P21589 Q6NZX3	A0A0C4DGX8 A0A384MQW4 Q15904
PDB IDs		4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I 6HXW
Enriched GO Terms of Interacting Partners?
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