NT5E and AFF1

Number of citations of the paper that reports this interaction (PubMedID 19956800)
85

Data Source:
BioGRID (two hybrid)

		NT5E	AFF1
Description		5'-nucleotidase ecto	AF4/FMR2 family member 1
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Exosome	Nucleus Transcription Elongation Factor Complex ELL-EAF Complex
	Molecular Function	Nucleotide Binding 5'-nucleotidase Activity Metal Ion Binding	Protein Binding
	Biological Process	Purine Nucleotide Catabolic Process AMP Catabolic Process DNA Metabolic Process Leukocyte Cell-cell Adhesion Dephosphorylation NAD Metabolic Process Adenosine Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Negative Regulation Of Inflammatory Response	Regulation Of Transcription, DNA-templated Regulation Of Gene Expression
Pathways		Nicotinate metabolism Pyrimidine catabolism Purine catabolism Purinergic signaling in leishmaniasis infection
Drugs		Pentoxifylline
Diseases		Calcification of joints and arteries	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Blood metabolite levels ( 24816252) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolic traits ( 21886157)	Alzheimer's disease (cognitive decline) ( 23535033) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Bulimia nervosa ( 23568457) Diastolic blood pressure ( 28234671) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 29403010 27863252) Hemoglobin ( 29403010) Hemoglobin concentration ( 27863252) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Red blood cell count ( 27863252) Systemic lupus erythematosus ( 22291604) Total bilirubin levels ( 29403010) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20864672 30275531 25961943 20686565) White blood cell count (basophil) ( 29403010 27863252)
Interacting Genes		5 interacting genes: ACTB AFF1 ATP6AP1 FN1 LAMA1	9 interacting genes: H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9 TBCA
Entrez ID		4907	4299
HPRD ID		00552	08871
Ensembl ID		ENSG00000135318	ENSG00000172493
Uniprot IDs		P21589 Q6NZX3	B4DJU9 P51825 Q14C88
PDB IDs		4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I 6HXW	2LM0
Enriched GO Terms of Interacting Partners?
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