NID1 and FBLN1

Number of citations of the paper that reports this interaction (PubMedID 9278415)
21

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NID1	FBLN1
Description		nidogen 1	fibulin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Plasma Membrane Receptor Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Collagen Binding Wnt-protein Binding Wnt-activated Receptor Activity Laminin Binding Laminin-1 Binding Proteoglycan Binding	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding
	Biological Process	Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Glomerular Basement Membrane Development Canonical Wnt Signaling Pathway Basement Membrane Organization	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Laminin interactions Laminin interactions	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Urokinase
Diseases			Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS		Blood protein levels ( 30072576) Cutaneous nevi ( 21478494) Diverticulitis ( 28585551) Urate levels in overweight individuals ( 25811787)	Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		21 interacting genes: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL	39 interacting genes: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MCPH1 MFAP5 MOB4 NEDD1 NID1 NLGN3 NOTCH3 PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 TLE5 VCAN YWHAQ
Entrez ID		4811	2192
HPRD ID		00574	00629
Ensembl ID		ENSG00000116962	ENSG00000077942
Uniprot IDs		P14543	P23142 Q8NBH6
PDB IDs		1NDX
Enriched GO Terms of Interacting Partners?
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