NEDD9 and PTK2B

Number of citations of the paper that reports this interaction (PubMedID 9020138)
32

Data Source:
HPRD (in vivo)

		NEDD9	PTK2B
Description		neural precursor cell expressed, developmentally down-regulated 9	protein tyrosine kinase 2 beta
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Cytosol Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium	Cell Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Postsynaptic Density NMDA Selective Glutamate Receptor Complex Lamellipodium Dendrite Growth Cone Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Dendritic Spine Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Apical Dendrite Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Tyrosine Kinase Binding	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity NMDA Glutamate Receptor Activity Protein Binding ATP Binding Protein C-terminus Binding Ubiquitin Protein Ligase Binding 3-phosphoinositide-dependent Protein Kinase Binding Protein-containing Complex Binding
	Biological Process	Cytoskeleton Organization Cell Cycle Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Regulation Of Growth Actin Filament Bundle Assembly Cell Division Positive Regulation Of Protein Tyrosine Kinase Activity Actin Filament Reorganization Activation Of GTPase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	MAPK Cascade Angiogenesis Oocyte Maturation Response To Hypoxia Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Adaptive Immune Response Marginal Zone B Cell Differentiation Protein Phosphorylation Apoptotic Process Cellular Defense Response Response To Osmotic Stress Signal Transduction Cell Surface Receptor Signaling Pathway Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Response To Mechanical Stimulus Response To Hormone Response To Glucose Response To Lithium Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of CGMP-mediated Signaling Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuron Projection Development Glial Cell Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Actin Filament Polymerization Neuron Projection Development Regulation Of Inositol Trisphosphate Biosynthetic Process Tumor Necrosis Factor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Response To Immobilization Stress Peptidyl-tyrosine Autophosphorylation Interleukin-2-mediated Signaling Pathway Response To Cocaine Response To Hydrogen Peroxide Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Stress Fiber Assembly Negative Regulation Of Potassium Ion Transport Positive Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Response To Ethanol Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Calcium-mediated Signaling Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To CAMP Response To Calcium Ion Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Protein-containing Complex Assembly Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Fluid Shear Stress Endothelin Receptor Signaling Pathway Activation Of GTPase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Establishment Of Cell Polarity Regulation Of Actin Cytoskeleton Reorganization Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of B Cell Chemotaxis Positive Regulation Of DNA Biosynthetic Process
Pathways			Signal regulatory protein family interactions VEGFA-VEGFR2 Pathway Interleukin-2 signaling
Drugs			Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide Baricitinib
Diseases
GWAS		Childhood dental caries in permanent teeth ( 29931343) Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) HIV-1 susceptibility ( 22174851) Macular thickness ( 30535121) Prostate cancer ( 25217961) Small cell lung carcinoma ( 28604730)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral content ( 31790847) Bone mineral density ( 31790847) Crohn's disease ( 26192919) Dental caries ( 23259602) Family history of Alzheimer's disease ( 30617256) Inflammatory bowel disease ( 26192919) Schizophrenia ( 29483656) Takayasu arteritis ( 25604533 30498034)
Interacting Genes		45 interacting genes: ABL1 APP AURKA BANP BCAR1 BCAR3 CDH1 CHAT CRK CRKL DIMT1 DMRTB1 ELSPBP1 FYN FZR1 ID2 ITCH LCK LYN MICAL1 NAB2 NCK1 NFKBIA NOTCH3 PIK3CA PRR20A PTK2 PTK2B PTPN11 PTPN12 PXN RAPGEF1 RBPMS REL RFX6 SH2D3C SMAD1 SMAD2 SMAD3 TCF3 TFCP2 TRIM27 TRIP6 ZNF318 ZYX	69 interacting genes: ARHGAP21 ARHGAP5 ASAP1 ASAP2 BCAR1 CBL CCR5 CRK DLG3 DLG4 DLGAP3 EFS EGFR ERBB2 ERBB3 EWSR1 FGFR2 FGFR3 FLT1 FYN GNA13 GRB2 GRIN2A GSN IL7R ITGB2 ITGB3 JAK1 JAK2 JAK3 KCNA2 LCK LPXN LYN MAP3K4 MAPT MATK MCAM MYH2 NEDD9 NPHP1 PDCD6IP PDPK1 PIK3R1 PITPNM1 PITPNM2 PITPNM3 PRKCD PTK2 PTPN11 PTPN12 PTPN6 PXN RASA1 RB1CC1 SH2D3C SHC1 SKAP2 SLC2A1 SNCA SORBS2 SRC STAP1 STAT3 SYK TGFB1I1 TLN1 VAV1 ZAP70
Entrez ID		4739	2185
HPRD ID		11888	03131
Ensembl ID		ENSG00000111859	ENSG00000120899
Uniprot IDs		A0A024QZV9 A0A087WUD2 Q14511	Q14289
PDB IDs		2L81 5X3S	2FO6 2LK4 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3F 4EKU 4H1J 4H1M 4R32 4XEF 4XEK 4XEV 5TO8 5TOB
Enriched GO Terms of Interacting Partners?
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