NEDD9 and SH2D3C

Number of citations of the paper that reports this interaction (PubMedID 10692442)
23

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		NEDD9	SH2D3C
Description		neural precursor cell expressed, developmentally down-regulated 9	SH2 domain containing 3C
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Cytosol Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium	Cytoplasm Membrane
	Molecular Function	Protein Binding Protein Tyrosine Kinase Binding	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Cytoskeleton Organization Cell Cycle Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Regulation Of Growth Actin Filament Bundle Assembly Cell Division Positive Regulation Of Protein Tyrosine Kinase Activity Actin Filament Reorganization Activation Of GTPase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation
Pathways
Drugs
Diseases
GWAS		Childhood dental caries in permanent teeth ( 29931343) Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) HIV-1 susceptibility ( 22174851) Macular thickness ( 30535121) Prostate cancer ( 25217961) Small cell lung carcinoma ( 28604730)	Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252)
Interacting Genes		45 interacting genes: ABL1 APP AURKA BANP BCAR1 BCAR3 CDH1 CHAT CRK CRKL DIMT1 DMRTB1 ELSPBP1 FYN FZR1 ID2 ITCH LCK LYN MICAL1 NAB2 NCK1 NFKBIA NOTCH3 PIK3CA PRR20A PTK2 PTK2B PTPN11 PTPN12 PXN RAPGEF1 RBPMS REL RFX6 SH2D3C SMAD1 SMAD2 SMAD3 TCF3 TFCP2 TRIM27 TRIP6 ZNF318 ZYX	11 interacting genes: BCAR1 CARD11 EFS EGFR EPHB2 GOLGA2 MAPK1 NEDD9 PTK2B SNCAIP SRC
Entrez ID		4739	10044
HPRD ID		11888	05284
Ensembl ID		ENSG00000111859	ENSG00000095370
Uniprot IDs		A0A024QZV9 A0A087WUD2 Q14511	B4DG32 Q8N5H7
PDB IDs		2L81 5X3S	3T6G
Enriched GO Terms of Interacting Partners?
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