NEDD9 and CHAT

Number of citations of the paper that reports this interaction (PubMedID 10692442)
23

Data Source:
HPRD (in vivo)

		NEDD9	CHAT
Description		neural precursor cell expressed, developmentally down-regulated 9	choline O-acetyltransferase
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Cytosol Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium	Nucleus Cytoplasm Cytosol Neuron Projection Presynapse
	Molecular Function	Protein Binding Protein Tyrosine Kinase Binding	Choline O-acetyltransferase Activity
	Biological Process	Cytoskeleton Organization Cell Cycle Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Regulation Of Growth Actin Filament Bundle Assembly Cell Division Positive Regulation Of Protein Tyrosine Kinase Activity Actin Filament Reorganization Activation Of GTPase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Phosphatidylcholine Biosynthetic Process Neurotransmitter Secretion Neuromuscular Synaptic Transmission Acetylcholine Biosynthetic Process
Pathways			Synthesis of PC Acetylcholine Neurotransmitter Release Cycle
Drugs			Nicotine
Diseases			Congenital myasthenic syndrome
GWAS		Childhood dental caries in permanent teeth ( 29931343) Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) HIV-1 susceptibility ( 22174851) Macular thickness ( 30535121) Prostate cancer ( 25217961) Small cell lung carcinoma ( 28604730)	Glaucoma (primary angle closure) ( 27064256) Interleukin-1-receptor antagonist levels ( 22205395) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes nephropathy ( 30566433)
Interacting Genes		45 interacting genes: ABL1 APP AURKA BANP BCAR1 BCAR3 CDH1 CHAT CRK CRKL DIMT1 DMRTB1 ELSPBP1 FYN FZR1 ID2 ITCH LCK LYN MICAL1 NAB2 NCK1 NFKBIA NOTCH3 PIK3CA PRR20A PTK2 PTK2B PTPN11 PTPN12 PXN RAPGEF1 RBPMS REL RFX6 SH2D3C SMAD1 SMAD2 SMAD3 TCF3 TFCP2 TRIM27 TRIP6 ZNF318 ZYX	9 interacting genes: CAMK2A CAMK2G NEDD9 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ
Entrez ID		4739	1103
HPRD ID		11888	07510
Ensembl ID		ENSG00000111859	ENSG00000070748
Uniprot IDs		A0A024QZV9 A0A087WUD2 Q14511	D3DX95 P28329 Q6LEN5 Q6LEN6
PDB IDs		2L81 5X3S	2FY2 2FY3 2FY4 2FY5
Enriched GO Terms of Interacting Partners?
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