DYNLL2 and RASGRP3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DYNLL2	RASGRP3
Description		dynein light chain LC8-type 2	RAS guanyl releasing protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Postsynaptic Density Membrane Dynein Complex Myosin V Complex Ciliary Tip Postsynapse Glutamatergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Scaffold Protein Binding	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Kinase Binding Diacylglycerol Binding
	Biological Process	ER To Golgi Vesicle-mediated Transport Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Intraciliary Transport Involved In Cilium Assembly Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed	MAPK Cascade Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Activation of RAS in B cells Activation of RAS in B cells RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Albumin-globulin ratio ( 29403010) Bronchopulmonary dysplasia in preterm infants ( 30113228) Hypertension (young onset) ( 19421330) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Non-albumin protein levels ( 29403010) Non-response to antidepressants and depression ( 27622933) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26663301 28714469 19838193)
Interacting Genes		21 interacting genes: BCL2L11 BMF C12orf40 DLGAP1 DNAL4 DYNC1I1 EWSR1 GPHN GPRIN2 HMBOX1 HOMER3 IHO1 MEOX2 MORN3 MYO5A PAK1 RASGRP3 SECISBP2L SKAP1 THAP10 XIAP	9 interacting genes: APP DYNLL2 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2
Entrez ID		140735	25780
HPRD ID		06489	15213
Ensembl ID		ENSG00000264364	ENSG00000152689
Uniprot IDs		Q96FJ2	Q8IV61
PDB IDs		2XQQ 3P8M 4D07
Enriched GO Terms of Interacting Partners?
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