MUC1 and HSPA4

Number of citations of the paper that reports this interaction (PubMedID 16158055)
64

Data Source:
BioGRID (pull down)

		MUC1	HSPA4
Description		mucin 1, cell surface associated	heat shock protein family A (Hsp70) member 4
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Vesicle Extracellular Exosome	Nucleus Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding P53 Binding Transcription Coregulator Activity Protein Binding	Protein Binding ATP Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Transcription By Competitive Promoter Binding O-glycan Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly
Pathways		Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family Interleukin-4 and Interleukin-13 signaling O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Regulation of HSF1-mediated heat shock response
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908 21102463) Estimated glomerular filtration rate ( 31015462) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric cancer ( 26098866 26129866 31383772) Gout ( 31578528) Inflammatory bowel disease ( 28067908) Magnesium levels ( 20700443 25886283 26058915) Non-cardia gastric cancer ( 26701879) Serum magnesium levels ( 29093028) Serum uric acid levels ( 30993211 29403010) Urinary albumin-to-creatinine ratio ( 26631737) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)	Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Eyebrow thickness ( 26926045) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Reticulocyte fraction of red cells ( 27863252) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		33 interacting genes: ABL1 APC BMI1 CTNNB1 CTNND1 EGFR ERBB2 ERBB3 ERBB4 ESR1 EZH2 GALNT1 GALNT10 GALNT12 GALNT15 GALNT2 GALNT4 GRB2 GSK3B HSP90AA1 HSPA4 JUP LCK LYN NUP62 OSGEP PPARG PRKCD SIGLEC1 SOS1 SRC TP53 ZAP70	65 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 RAF1 RAP1A REL RELA SGTA SIRPA SMAD3 ST13 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE3A
Entrez ID		4582	3308
HPRD ID		01152	09025
Ensembl ID		ENSG00000185499	ENSG00000170606
Uniprot IDs		A0A087X0L2 A0A087X2A4 A0A0A0MRB3 A0A0C4DGW3 A0A384NPK6 A5YRU5 A5YRU7 A5YRV0 A5YRV2 A6ZID6 A6ZID7 A6ZIE4 A6ZIE6 B6ECB3 P15941 Q7Z538 Q7Z551	P34932
PDB IDs		1SM3 2ACM 2FO4 5T6P 5T78 6FZQ 6FZR
Enriched GO Terms of Interacting Partners?
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