MUC1 and GALNT1

Number of citations of the paper that reports this interaction (PubMedID 9295285)
64

Data Source:
HPRD (in vitro)

		MUC1	GALNT1
Description		mucin 1, cell surface associated	polypeptide N-acetylgalactosaminyltransferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Vesicle Extracellular Exosome	Golgi Membrane Extracellular Region Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding P53 Binding Transcription Coregulator Activity Protein Binding	Polypeptide N-acetylgalactosaminyltransferase Activity Manganese Ion Binding Carbohydrate Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Transcription By Competitive Promoter Binding O-glycan Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Protein O-linked Glycosylation O-glycan Processing Protein O-linked Glycosylation Via Serine Protein O-linked Glycosylation Via Threonine
Pathways		Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family Interleukin-4 and Interleukin-13 signaling O-linked glycosylation of mucins Termination of O-glycan biosynthesis	COPI-independent Golgi-to-ER retrograde traffic O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908 21102463) Estimated glomerular filtration rate ( 31015462) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric cancer ( 26098866 26129866 31383772) Gout ( 31578528) Inflammatory bowel disease ( 28067908) Magnesium levels ( 20700443 25886283 26058915) Non-cardia gastric cancer ( 26701879) Serum magnesium levels ( 29093028) Serum uric acid levels ( 30993211 29403010) Urinary albumin-to-creatinine ratio ( 26631737) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)	Drug-induced torsades de pointes ( 24223155) Post bronchodilator FEV1 ( 26634245) Serum sclerostin levels ( 31170332) Superior parietal cortex volume ( 31530798)
Interacting Genes		33 interacting genes: ABL1 APC BMI1 CTNNB1 CTNND1 EGFR ERBB2 ERBB3 ERBB4 ESR1 EZH2 GALNT1 GALNT10 GALNT12 GALNT15 GALNT2 GALNT4 GRB2 GSK3B HSP90AA1 HSPA4 JUP LCK LYN NUP62 OSGEP PPARG PRKCD SIGLEC1 SOS1 SRC TP53 ZAP70	3 interacting genes: MUC1 PTPRF SEC23B
Entrez ID		4582	2589
HPRD ID		01152	03781
Ensembl ID		ENSG00000185499	ENSG00000141429
Uniprot IDs		A0A087X0L2 A0A087X2A4 A0A0A0MRB3 A0A0C4DGW3 A0A384NPK6 A5YRU5 A5YRU7 A5YRV0 A5YRV2 A6ZID6 A6ZID7 A6ZIE4 A6ZIE6 B6ECB3 P15941 Q7Z538 Q7Z551	A0A024RC48 Q05BM8 Q10472
PDB IDs		1SM3 2ACM 2FO4 5T6P 5T78 6FZQ 6FZR
Enriched GO Terms of Interacting Partners?
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