MUC1 and GALNT2

Number of citations of the paper that reports this interaction (PubMedID 9295285)
64

Data Source:
HPRD (in vivo, in vitro)

		MUC1	GALNT2
Description		mucin 1, cell surface associated	polypeptide N-acetylgalactosaminyltransferase 2
Image
GO Annotations	Cellular Component	Nuclear Chromatin Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Vesicle Extracellular Exosome	Golgi Membrane Extracellular Region Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Membrane Integral Component Of Golgi Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding P53 Binding Transcription Coregulator Activity Protein Binding	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding Manganese Ion Binding Carbohydrate Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Transcription By Competitive Promoter Binding O-glycan Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Immunoglobulin Biosynthetic Process Protein O-linked Glycosylation O-glycan Processing Protein O-linked Glycosylation Via Serine Protein O-linked Glycosylation Via Threonine
Pathways		Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family Interleukin-4 and Interleukin-13 signaling O-linked glycosylation of mucins Termination of O-glycan biosynthesis	COPI-independent Golgi-to-ER retrograde traffic O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908 21102463) Estimated glomerular filtration rate ( 31015462) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric cancer ( 26098866 26129866 31383772) Gout ( 31578528) Inflammatory bowel disease ( 28067908) Magnesium levels ( 20700443 25886283 26058915) Non-cardia gastric cancer ( 26701879) Serum magnesium levels ( 29093028) Serum uric acid levels ( 30993211 29403010) Urinary albumin-to-creatinine ratio ( 26631737) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)	Blood protein levels ( 29875488) Carotid intima media thickness ( 26343869) Circulating myeloperoxidase levels (serum) ( 23620142) Coronary artery disease ( 29212778) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Fibrinogen levels ( 28107422) HDL cholesterol ( 24097068 18193043 18193044 20864672 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematology traits ( 23303382) High density lipoprotein cholesterol levels ( 29403010) Intake of sweets ( 31005972) Metabolic syndrome ( 22399527 31589552) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Platelet count ( 27863252) Postburn scar pliability ( 30595539) Red cell distribution width ( 27863252 28957414) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 28334899 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 18193043 18193044 30275531 25961943 20686565)
Interacting Genes		33 interacting genes: ABL1 APC BMI1 CTNNB1 CTNND1 EGFR ERBB2 ERBB3 ERBB4 ESR1 EZH2 GALNT1 GALNT10 GALNT12 GALNT15 GALNT2 GALNT4 GRB2 GSK3B HSP90AA1 HSPA4 JUP LCK LYN NUP62 OSGEP PPARG PRKCD SIGLEC1 SOS1 SRC TP53 ZAP70	3 interacting genes: KASH5 LMNA MUC1
Entrez ID		4582	2590
HPRD ID		01152	03782
Ensembl ID		ENSG00000185499	ENSG00000143641
Uniprot IDs		A0A087X0L2 A0A087X2A4 A0A0A0MRB3 A0A0C4DGW3 A0A384NPK6 A5YRU5 A5YRU7 A5YRV0 A5YRV2 A6ZID6 A6ZID7 A6ZIE4 A6ZIE6 B6ECB3 P15941 Q7Z538 Q7Z551	A0A1L7NY50 B7Z6K2 G3V1S6 Q10471
PDB IDs		1SM3 2ACM 2FO4 5T6P 5T78 6FZQ 6FZR	2FFU 2FFV 4D0T 4D0Z 4D11 5AJN 5AJO 5AJP 5FV9 5NDF 6EGS
Enriched GO Terms of Interacting Partners?
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