LAMTOR5 and PDK1

Number of citations of the paper that reports this interaction (PubMedID 23241634)
1

Data Source:
BioGRID (two hybrid)

		LAMTOR5	PDK1
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	pyruvate dehydrogenase kinase 1
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Ragulator Complex	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding
	Biological Process	Cell Cycle Arrest Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Viral Genome Replication Positive Regulation Of TOR Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Glucose Metabolic Process Protein Phosphorylation Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Glucose Homeostasis Hypoxia-inducible Factor-1alpha Signaling Pathway Negative Regulation Of Pyruvate Dehydrogenase Activity
Pathways		Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs			4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE Dichloroacetic Acid
Diseases
GWAS			Blood protein levels ( 28240269) Erectile dysfunction in type 1 diabetes ( 22704111) Fasting plasma glucose ( 25187374)
Interacting Genes		32 interacting genes: ALB ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLCC1 DBI EEF1A1 GAPDH GIT1 GPRASP1 LAMTOR4 LRIF1 MAF1 MCPH1 MEOX2 MT2A NCOA6 PDK1 RABIF RBP4 SERPINA1 TAF9 TGFB1 TOP2B TP53 UTP14A YTHDC1 ZBTB16	15 interacting genes: AKT1 COL6A1 DLAT FGFR1 ITGB3 KAT2B LAMTOR5 PDHA1 PDK2 PIK3CA RPS6KB1 SGK1 USP4 XRCC6 YWHAQ
Entrez ID		10542	5163
HPRD ID		09773	03954
Ensembl ID		ENSG00000134248	ENSG00000152256
Uniprot IDs		A0A0C4DGV4 O43504	B7Z7N6 Q15118
PDB IDs		3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG	2Q8F 2Q8G 2Q8H
Enriched GO Terms of Interacting Partners?
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