TRAF3 and MAP2K1

Number of citations of the paper that reports this interaction (PubMedID 8626767)
18

Data Source:
HPRD (in vitro, in vivo)

		TRAF3	MAP2K1
Description		TNF receptor associated factor 3	mitogen-activated protein kinase kinase 1
Image
GO Annotations	Cellular Component	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Plasma Membrane Receptor Complex	Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Microtubule Organizing Center Cytosol Plasma Membrane Focal Adhesion
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Protein C-terminus Binding Protein Serine/threonine Kinase Activator Activity Protein N-terminus Binding Scaffold Protein Binding
	Biological Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Protein Deubiquitination Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of JNK Cascade Regulation Of Defense Response To Virus Protein K63-linked Ubiquitination	MAPK Cascade Activation Of MAPK Activity Protein Phosphorylation Chemotaxis Cell Cycle Arrest Signal Transduction Regulation Of Mitotic Cell Cycle Heart Development Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Cerebellar Cortex Formation Signal Transduction By Protein Phosphorylation Neuron Differentiation Keratinocyte Differentiation Thyroid Gland Development Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transcription, DNA-templated Thymus Development Regulation Of Axon Regeneration Cell Motility Positive Regulation Of Axonogenesis Bergmann Glial Cell Differentiation Face Development Trachea Formation Epithelial Cell Proliferation Involved In Lung Morphogenesis Placenta Blood Vessel Development Labyrinthine Layer Development ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Cellular Senescence Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Early Endosome To Late Endosome Transport
Pathways		TRAF3 deficiency - HSE TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ovarian tumor domain proteases TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	MAPK3 (ERK1) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs			K-252a 5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide Cobimetinib Bosutinib (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide PD-0325901 N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE Trametinib
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma (childhood onset) ( 30929738) Body mass index ( 25673413 29273807) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Eczema ( 31361310) Gallstone disease ( 30692554) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010) Systemic lupus erythematosus ( 28714469)	Prostate cancer ( 29892016) Testicular germ cell tumor ( 28604728 28604732)
Interacting Genes		61 interacting genes: ABCC1 ALPL APOBEC3C AZI2 BEX3 BIRC3 CASP3 CD27 CD40 CELF2 CSNK1E DAXX EDA2R EDAR EWSR1 FAS GRIN1 GRIN2D HNRNPC IL15 IRF1 LTBR MAP2K1 MAP3K14 MAP3K7 NUP62 OTUD5 PDLIM7 RIPK1 RNF216 RRAS2 SAR1A SRC STK38 TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM37 UBE2I USP7 ZBP1 ZMYND11	43 interacting genes: ARAF BANP BIRC6 BRAF CASP9 CDK5 CPNE1 CPNE4 EGFR ELK1 EP300 GRB10 HNRNPD HRAS KAT7 KSR1 KSR2 LAMTOR3 MAP3K4 MAP3K8 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP3 MYC PAK1 PARVA PEBP1 PEBP4 PLK3 PPARG PRKCI PRKCZ RAF1 RPS6KA2 RPS6KA4 TRAF3 TRAF6 TRIB1 UBE2I UBE2L3 WNK1
Entrez ID		7187	5604
HPRD ID		03539	01469
Ensembl ID		ENSG00000131323	ENSG00000169032
Uniprot IDs		A6NHG8 Q13114	A4QPA9 B4DFY5 H3BRW9 Q02750
PDB IDs		1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW	1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM 5HZE 5YT3 6NYB 6PP9 6Q0J 6Q0T 6U2G
Enriched GO Terms of Interacting Partners?
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