MMP14 and CLDN1

Number of citations of the paper that reports this interaction (PubMedID 11382769)
47

Data Source:
HPRD (in vivo)

		MMP14	CLDN1
Description		matrix metallopeptidase 14	claudin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Tight Junction
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Zinc Ion Binding Metalloaminopeptidase Activity	Virus Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Skeletal System Development Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Response To Hormone Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Response To Organic Cyclic Compound Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Craniofacial Suture Morphogenesis Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant	Aging Establishment Of Blood-nerve Barrier Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Positive Regulation Of Cell Migration Response To Lipopolysaccharide Cell Junction Maintenance Hyperosmotic Salinity Response Cell-cell Junction Organization Response To Ethanol Viral Entry Into Host Cell Protein Complex Oligomerization Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Establishment Of Skin Barrier Drug Transport Across Blood-nerve Barrier Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Lead Ion Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Wound Healing Establishment Of Endothelial Intestinal Barrier Liver Regeneration Positive Regulation Of Bicellular Tight Junction Assembly Cellular Response To Butyrate
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases	Tight junction interactions
Drugs		Marimastat
Diseases			Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome; Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC)
GWAS		Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549 28869591) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Optic disc size ( 31809533) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		26 interacting genes: ACAN ADI1 BCAR1 C1QBP CAV1 CCL7 CLDN1 F12 FURIN ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 PLLP RRAD SDC1 SPOCK1 SPOCK3 TIMP1 TIMP2 TIMP3 TIMP4	12 interacting genes: BRD4 CLDN3 DRG1 LNX1 MMP14 MMP2 MPDZ PATJ TJP1 TJP2 TJP3 WNK4
Entrez ID		4323	9076
HPRD ID		02856	04760
Ensembl ID		ENSG00000157227	ENSG00000163347
Uniprot IDs		P50281	A5JSJ9 O95832
PDB IDs		1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1
Enriched GO Terms of Interacting Partners?
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