MMP14 and TIMP2

Number of citations of the paper that reports this interaction (PubMedID 9724659)
75

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		MMP14	TIMP2
Description		matrix metallopeptidase 14	TIMP metallopeptidase inhibitor 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton	Extracellular Region Extracellular Space Cell Surface Growth Cone Extracellular Matrix Specific Granule Lumen Neuronal Cell Body Collagen-containing Extracellular Matrix Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Zinc Ion Binding Metalloaminopeptidase Activity	Protease Binding Integrin Binding Protein Binding Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity
	Biological Process	Skeletal System Development Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Response To Hormone Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Response To Organic Cyclic Compound Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Craniofacial Suture Morphogenesis Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant	Central Nervous System Development Aging Negative Regulation Of Cell Proliferation Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Regulation Of Rap Protein Signal Transduction Response To Cytokine Response To Drug Neutrophil Degranulation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metallopeptidase Activity
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases	Activation of Matrix Metalloproteinases Neutrophil degranulation
Drugs		Marimastat
Diseases
GWAS		Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549 28869591) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Blood protein levels ( 30072576) Dupuytren's disease ( 21732829) Heel bone mineral density ( 30598549) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Periodontitis (CDC/AAP) ( 24024966)
Interacting Genes		26 interacting genes: ACAN ADI1 BCAR1 C1QBP CAV1 CCL7 CLDN1 F12 FURIN ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 PLLP RRAD SDC1 SPOCK1 SPOCK3 TIMP1 TIMP2 TIMP3 TIMP4	5 interacting genes: ITGA3 ITGB1 MMP14 MMP2 MMP8
Entrez ID		4323	7077
HPRD ID		02856	01784
Ensembl ID		ENSG00000157227	ENSG00000035862
Uniprot IDs		P50281	A0A140VK57 P16035
PDB IDs		1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1	1BR9 1GXD 2TMP 4ILW
Enriched GO Terms of Interacting Partners?
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