TIMP2

Description		TIMP metallopeptidase inhibitor 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Growth Cone Extracellular Matrix Specific Granule Lumen Neuronal Cell Body Collagen-containing Extracellular Matrix Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding Integrin Binding Protein Binding Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity
	Biological Process	Central Nervous System Development Aging Negative Regulation Of Cell Proliferation Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Regulation Of Rap Protein Signal Transduction Response To Cytokine Response To Drug Neutrophil Degranulation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metallopeptidase Activity
Pathways		Activation of Matrix Metalloproteinases Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Dupuytren's disease ( 21732829) Heel bone mineral density ( 30598549) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Periodontitis (CDC/AAP) ( 24024966)
Interacting Genes		5 interacting genes: ITGA3 ITGB1 MMP14 MMP2 MMP8
Entrez ID		7077
HPRD ID		01784
Ensembl ID		ENSG00000035862
Uniprot IDs		A0A140VK57 P16035
PDB IDs		1BR9 1GXD 2TMP 4ILW
Enriched GO Terms of Interacting Partners?
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