AFDN and TJP1

Number of citations of the paper that reports this interaction (PubMedID 10334923)
16

Data Source:
HPRD (in vivo, in vitro)

		AFDN	TJP1
Description		afadin, adherens junction formation factor	tight junction protein 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction
	Molecular Function	Protein Binding Protein C-terminus Binding Ras GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding	Protein Binding Calmodulin Binding Cadherin Binding
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Adherens Junction Organization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Cell-cell Junction Assembly Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Hippo Signaling Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Maintenance Of Permeability Of Blood-brain Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Actin Cytoskeleton Reorganization Regulation Of Bicellular Tight Junction Assembly
Pathways			Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions
Drugs		(5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE
Diseases
GWAS		Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)	Central corneal thickness ( 31798171 29760442 30894546) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Interacting Genes		37 interacting genes: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 OCLN PEA15 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3
Entrez ID		4301	7082
HPRD ID		01164	03002
Ensembl ID		ENSG00000130396	ENSG00000104067
Uniprot IDs		A8MQ02 G1UI22 J3KN01 P55196	A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157 Q6MZU1
PDB IDs		1T2M 1XZ9 2AIN 2EXG 5A6C	2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?
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