AFDN and NECTIN1

Number of citations of the paper that reports this interaction (PubMedID 10225955)
139

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		AFDN	NECTIN1
Description		afadin, adherens junction formation factor	nectin cell adhesion molecule 1
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction	Extracellular Region Plasma Membrane Adherens Junction Membrane Integral Component Of Membrane Dendrite Growth Cone Membrane Intracellular Membrane-bounded Organelle Apical Junction Complex Cell-cell Contact Zone Hippocampal Mossy Fiber To CA3 Synapse Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Ras GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Carbohydrate Binding Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Virion Binding Cell Adhesion Molecule Binding
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Adherens Junction Organization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Lens Morphogenesis In Camera-type Eye Desmosome Organization Iron Ion Transport Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axon Guidance Virion Attachment To Host Cell Adherens Junction Organization Viral Entry Into Host Cell Regulation Of Synapse Assembly Retina Development In Camera-type Eye Enamel Mineralization Cell-cell Adhesion Protein Localization To Cell Junction
Pathways			Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs		(5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		37 interacting genes: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	10 interacting genes: AFDN CBL FGFR1 FGFR2 FGFR3 NECTIN3 NECTIN4 PARD3 PRNP PVR
Entrez ID		4301	5818
HPRD ID		01164	07200
Ensembl ID		ENSG00000130396	ENSG00000110400
Uniprot IDs		A8MQ02 G1UI22 J3KN01 P55196	Q15223
PDB IDs		1T2M 1XZ9 2AIN 2EXG 5A6C	3ALP 3SKU 3U82 3U83 4FMF 4MYW
Enriched GO Terms of Interacting Partners?
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