ASCL1 and UBQLN1

Number of citations of the paper that reports this interaction (PubMedID 15492808)
3

Data Source:
HPRD (two hybrid)

		ASCL1	UBQLN1
Description		achaete-scute family bHLH transcription factor 1	ubiquilin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Neuronal Cell Body RNA Polymerase II Transcription Factor Complex	Proteasome Complex Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Aggresome Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Identical Protein Binding BHLH Transcription Factor Binding Protein Dimerization Activity E-box Binding	Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Noradrenergic Neuron Development Noradrenergic Neuron Fate Commitment Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Neuroblast Fate Determination Neuroblast Proliferation Sensory Organ Development Heart Development Response To Lithium Ion Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Association Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Vestibular Nucleus Development Cerebral Cortex GABAergic Interneuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Cerebral Cortex Development Neurogenesis Neuron Differentiation Regulation Of Epithelial Cell Differentiation Response To Retinoic Acid Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Sympathetic Nervous System Development Neuron Fate Commitment Neuron Fate Specification Neuron Development Regulation Of Neurogenesis Musculoskeletal Movement, Spinal Reflex Action Response To Folic Acid Subpallium Neuron Fate Commitment Regulation Of Timing Of Subpallium Neuron Differentiation Olfactory Pit Development Lung Epithelial Cell Differentiation Ventral Spinal Cord Interneuron Fate Commitment Lung Neuroendocrine Cell Differentiation Stomach Neuroendocrine Cell Differentiation Carotid Body Glomus Cell Differentiation Adrenal Chromaffin Cell Differentiation Sympathetic Ganglion Development Response To Epidermal Growth Factor Cellular Response To Magnetism Positive Regulation Of Neural Precursor Cell Proliferation	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Macroautophagy Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Aggrephagy Cellular Response To Hypoxia Autophagosome Maturation Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		NGF-stimulated transcription NGF-stimulated transcription	Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases		Congenital central hypoventilation syndrome (CCHS)
GWAS		C-reactive protein levels ( 30388399 21300955) Menopause (age at onset) ( 26414677) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)	Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: BMP2 EP300 MEF2A MEF2C MEF2D MTNR1A NEUROG2 TCF4 UBQLN1	164 interacting genes: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 APP ASCL1 ATXN3 BPIFA1 C1QA C1QTNF2 CALU CCL7 CD47 CD99 CD99L2 CHGB CHRNA3 CHRNA4 CHRNB4 CLCN2 COL10A1 COL1A2 COLGALT2 COMTD1 COPS4 CSTF2 CSTF2T CTAG1B CTAG2 CYB5R1 DEFA6 DNAJB2 DOLK EFEMP2 EP300 EPS15 ERP27 ETNK1 F8 FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GHRL GIT2 GKAP1 GPX3 GRM2 GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 KLHL42 LHX4 LITAF MANBAL MAP3K1 MCM7 MIEF1 MIEF2 MLLT6 MTNR1A MTOR NAXD NBL1 NDE1 NEDD8 NGLY1 NLGN3 NME3 NPPA NPY NT5C3A NUP58 P4HB PARVA PBXIP1 PIK3IP1 PLAAT3 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PSEN1 PSEN2 PSMD4 PSMD6 PTN RARA RASSF5 RIC8A RNF208 RPN1 RSRC2 RTL8A RTL8B RTL8C SCG2 SCG5 SCMH1 SERPINE1 SERPINI2 SIL1 SLC29A2 SMAD9 SMIM2 SMR3B SMURF1 SPARC SRGN STMN3 SYNJ2BP TARDBP TFF1 TICAM1 TLR4 TMCO6 TMEM31 TMEM37 TMEM67 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM32 TXNDC12 UBB UBC UBE2V1 UBE3A UBQLN4 UBXN1 WBP2 XPO4 ZFAND2B ZG16 ZG16B ZNF343
Entrez ID		429	29979
HPRD ID		00011	05440
Ensembl ID		ENSG00000139352	ENSG00000135018
Uniprot IDs		P50553	A0A024R258 Q9UMX0
PDB IDs			2JY5 2JY6 2KLC
Enriched GO Terms of Interacting Partners?
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