UBQLN1 and HGS

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		UBQLN1	HGS
Description		ubiquilin 1	hepatocyte growth factor-regulated tyrosine kinase substrate
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Aggresome Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Lysosome Endosome Early Endosome Cytosol Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding	Protein Binding Protein Domain Specific Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Macroautophagy Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Aggrephagy Cellular Response To Hypoxia Autophagosome Maturation Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process	Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Protein Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of MAP Kinase Activity Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion
Pathways		Cargo recognition for clathrin-mediated endocytosis	EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion
Drugs			Citric Acid
Diseases
GWAS		Metabolite levels ( 23823483)	Eye color traits ( 20463881)
Interacting Genes		164 interacting genes: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 APP ASCL1 ATXN3 BPIFA1 C1QA C1QTNF2 CALU CCL7 CD47 CD99 CD99L2 CHGB CHRNA3 CHRNA4 CHRNB4 CLCN2 COL10A1 COL1A2 COLGALT2 COMTD1 COPS4 CSTF2 CSTF2T CTAG1B CTAG2 CYB5R1 DEFA6 DNAJB2 DOLK EFEMP2 EP300 EPS15 ERP27 ETNK1 F8 FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GHRL GIT2 GKAP1 GPX3 GRM2 GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 KLHL42 LHX4 LITAF MANBAL MAP3K1 MCM7 MIEF1 MIEF2 MLLT6 MTNR1A MTOR NAXD NBL1 NDE1 NEDD8 NGLY1 NLGN3 NME3 NPPA NPY NT5C3A NUP58 P4HB PARVA PBXIP1 PIK3IP1 PLAAT3 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PSEN1 PSEN2 PSMD4 PSMD6 PTN RARA RASSF5 RIC8A RNF208 RPN1 RSRC2 RTL8A RTL8B RTL8C SCG2 SCG5 SCMH1 SERPINE1 SERPINI2 SIL1 SLC29A2 SMAD9 SMIM2 SMR3B SMURF1 SPARC SRGN STMN3 SYNJ2BP TARDBP TFF1 TICAM1 TLR4 TMCO6 TMEM31 TMEM37 TMEM67 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM32 TXNDC12 UBB UBC UBE2V1 UBE3A UBQLN4 UBXN1 WBP2 XPO4 ZFAND2B ZG16 ZG16B ZNF343	182 interacting genes: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG C1orf94 CASK CBS CCDC103 CCDC114 CCDC136 CCDC33 CDR2 CEP55 CEP57L1 CEP63 CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DNAJC5 DYDC1 EGFR EHMT2 EPS15 ESRRG EXOC5 EXOC7 EXOC8 FAM168A FANCG FCHSD2 FLOT1 FLOT2 GFAP GFI1B GGA2 GKAP1 GOLGA2 HAP1 HNRNPDL HSFY1 HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KIAA0753 KRT13 KRT15 KRT18 KRT19 KRT31 KRT33B KRT38 KRT40 KRT6A KRTAP26-1 LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD8 NEFL NF2 NMI NPAS2 NUP54 NUP62 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 PMEPA1 PNMA1 POGZ PPP1R16A PPP1R7 PTCD3 RBCK1 RFX6 RHOBTB3 RINT1 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 SS18L1 STAM STAM2 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TEKT1 TFG TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TRAF4 TRAK1 TRAP1 TRIM17 TRIM27 TRIM69 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 ZNF302
Entrez ID		29979	9146
HPRD ID		05440	05085
Ensembl ID		ENSG00000135018	ENSG00000185359
Uniprot IDs		A0A024R258 Q9UMX0	A0A0S2Z4R4 O14964
PDB IDs		2JY5 2JY6 2KLC	2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?