MIA2 and EMILIN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MIA2	EMILIN1
Description		MIA SH3 domain ER export factor 2	elastin microfibril interfacer 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Endoplasmic Reticulum Exit Site	Extracellular Region Collagen Trimer Extracellular Space Integrin Alpha4-beta1 Complex Collagen-containing Extracellular Matrix Extracellular Exosome EMILIN Complex
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Integrin Binding Involved In Cell-matrix Adhesion
	Biological Process	ER To Golgi Vesicle-mediated Transport Protein Secretion Cargo Loading Into Vesicle	Aortic Valve Morphogenesis Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Elastic Fiber Assembly Negative Regulation Of Cell Activation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Macrophage Migration
Pathways		Cargo concentration in the ER	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS
Interacting Genes		13 interacting genes: CCHCR1 CEP57 DGCR6 EMILIN1 GRB2 MAGEB18 PSMA3 RASAL2 SEC23A SEC24C SS18L1 TLE5 TTC23L	15 interacting genes: BEX3 BEX5 COG7 DYNC1I1 EMILIN2 IFT20 LAIR2 MIA2 MTMR9 NECAB2 NMI PLAC9 RIBC1 YJU2 ZC2HC1C
Entrez ID		4253	11117
HPRD ID		03680	00563
Ensembl ID		ENSG00000150527	ENSG00000138080
Uniprot IDs		Q4G155 Q59FD2 Q96PC5	Q9Y6C2
PDB IDs			2KA3 2OII
Enriched GO Terms of Interacting Partners?
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