MECP2 and LBR

Number of citations of the paper that reports this interaction (PubMedID 19331822)
30

Data Source:
BioGRID (affinity chromatography technology, pull down, imaging technique)

		MECP2	LBR
Description		methyl-CpG binding protein 2	lamin B receptor
Image
GO Annotations	Cellular Component	Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Mitochondrion Centrosome Cytosol Postsynapse	Nucleus Nuclear Envelope Nuclear Inner Membrane Integral Component Of Nuclear Inner Membrane Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Transcription Factor Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Protein Domain Specific Binding SiRNA Binding Protein N-terminus Binding	DNA Binding RNA Binding Protein Binding Lamin Binding Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Delta14-sterol Reductase Activity Chromo Shadow Domain Binding NADPH Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Response To Hypoxia Startle Response Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Respiratory Gaseous Exchange By Neurological System Process Inositol Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Transcription Initiation From RNA Polymerase II Promoter Glutamine Metabolic Process Cellular Biogenic Amine Metabolic Process Mitotic Spindle Organization Synapse Assembly Respiratory Gaseous Exchange Long-term Memory Locomotory Behavior Protein Localization Glucocorticoid Metabolic Process Positive Regulation Of Cell Proliferation Adult Locomotory Behavior Visual Learning Response To Radiation Pathogenesis Post-embryonic Development Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Dendrite Development Negative Regulation Of Angiogenesis Histone Methylation Histone Acetylation Proprioception Sensory Perception Of Pain Cerebellum Development Ventricular System Development Cardiolipin Metabolic Process Social Behavior Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylcholine Metabolic Process Catecholamine Secretion Negative Regulation Of Smooth Muscle Cell Differentiation Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Positive Regulation Of Microtubule Nucleation Positive Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of DNA Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Neutrophil Differentiation Oxidation-reduction Process
Pathways			Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation Regulation of MECP2 expression and activity
Drugs
Diseases		Non-syndromic X-linked mental retardation Rett syndrome Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)	HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly
GWAS		Non-albumin protein levels ( 29403010) Red blood cell traits ( 23446634) Schizophrenia ( 24043878) Systemic lupus erythematosus ( 26663301 26502338 19838195)	Delirium ( 29631748)
Interacting Genes		20 interacting genes: DNMT1 DNMT3L GTF2B H3C15 HDAC1 HIPK2 HMGB1 LBR NCOR1 PRKACA PRPF40A PRPF40B SIN3A SKI SMARCA2 SMARCB1 SOX18 SPI1 TBL1X TBL1XR1	11 interacting genes: AKAP8L CBX3 CBX5 FNBP4 H4C14 LMNB1 MECP2 PRM1 SRPK1 SRPK2 YWHAG
Entrez ID		4204	3930
HPRD ID		02050	02488
Ensembl ID		ENSG00000169057	ENSG00000143815
Uniprot IDs		A0A140VKC4 D3YJ43 P51608 Q59FJ6	Q14739
PDB IDs		1QK9 3C2I 5BT2 6C1Y 6OGJ 6OGK	2DIG
Enriched GO Terms of Interacting Partners?
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