LBR and CBX3

Number of citations of the paper that reports this interaction (PubMedID 8663349)
125

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		LBR	CBX3
Description		lamin B receptor	chromobox 3
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Integral Component Of Nuclear Inner Membrane Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nuclear Chromosome, Telomeric Region Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin Spindle Nuclear Pericentric Heterochromatin Senescence-associated Heterochromatin Focus Site Of DNA Damage
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Delta14-sterol Reductase Activity Chromo Shadow Domain Binding NADPH Binding	Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Neutrophil Differentiation Oxidation-reduction Process	Chromatin Remodeling Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of G0 To G1 Transition Cellular Response To Dexamethasone Stimulus
Pathways		Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation Regulation of MECP2 expression and activity	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs
Diseases		HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly
GWAS		Delirium ( 29631748)	Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		11 interacting genes: AKAP8L CBX3 CBX5 FNBP4 H4C14 LMNB1 MECP2 PRM1 SRPK1 SRPK2 YWHAG	32 interacting genes: ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 DNMT3B DSN1 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 KLF11 L3MBTL1 LBR MGA MIS12 MKI67 NSD3 NSL1 PIM1 SP100 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF496
Entrez ID		3930	11335
HPRD ID		02488	05130
Ensembl ID		ENSG00000143815	ENSG00000122565
Uniprot IDs		Q14739	A4D177 Q13185
PDB IDs		2DIG	2L11 3DM1 3KUP 3TZD 5T1I
Enriched GO Terms of Interacting Partners?
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