MDM2 and VEGFA

  • Number of citations of the paper that reports this interaction (PubMedID 28274247)
  • 9
  • Data Source:
  • BioGRID (affinity chromatography technology, unspecified method)

MDM2

VEGFA

Description MDM2 proto-oncogene vascular endothelial growth factor A
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Pneumoconiosis in silica exposure ( 24986923)
  • Adiponectin levels ( 22479202)
  • Advanced age-related macular degeneration ( 26691988)
  • Age-related macular degeneration ( 23455636 21665990)
  • Blood protein levels ( 30072576 29875488)
  • Body mass index ( 25673413)
  • Chronic kidney disease ( 20383146)
  • Coronary artery disease ( 29212778)
  • Coronary heart disease ( 22319020)
  • Creatinine levels ( 31015462 29124443 29403010)
  • Cytokine levels ( 31679650)
  • Cytokine network levels (multivariate analysis) ( 31679650)
  • Diastolic blood pressure ( 30224653)
  • Estimated glomerular filtration rate ( 31015462 29124443 30604766)
  • Fasting glucose change (short-term) ( 31263163)
  • Glomerular filtration rate ( 27588450 29403010)
  • Glomerular filtration rate (creatinine) ( 28452372 26831199)
  • Glomerular filtration rate in non diabetics (creatinine) ( 26831199)
  • HDL cholesterol ( 24097068)
  • HDL cholesterol levels ( 28334899 30698716)
  • HDL cholesterol levels in current drinkers ( 30698716)
  • HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
  • Heel bone mineral density ( 30598549)
  • Hematocrit ( 27863252)
  • Hemoglobin concentration ( 27863252)
  • High density lipoprotein cholesterol levels ( 29403010)
  • High light scatter reticulocyte percentage of red cells ( 27863252)
  • Hyperthyroidism ( 30367059)
  • Hyperuricemia ( 29124443)
  • Hypothyroidism ( 27182965)
  • Interleukin-10 levels ( 27989323)
  • Interleukin-12p70 levels ( 27989323)
  • Interleukin-13 levels ( 27989323)
  • Interleukin-7 levels ( 27989323)
  • Medication use (calcium channel blockers) ( 31015401)
  • Medication use (HMG CoA reductase inhibitors) ( 31015401)
  • Metabolic syndrome ( 31589552)
  • Myeloid white cell count ( 27863252)
  • Plasma thyroid-stimulating hormone levels ( 28333968)
  • Prostate-specific antigen levels ( 28139693)
  • Red blood cell count ( 27863252)
  • Reticulocyte count ( 27863252)
  • Reticulocyte fraction of red cells ( 27863252)
  • Serum uric acid levels ( 30993211 29124443)
  • Sexual dimorphism in anthropometric traits ( 23754948)
  • Thyroid hormone levels ( 23408906)
  • Thyroid stimulating hormone levels ( 25743335)
  • Triglyceride levels ( 28334899 29403010 30698716)
  • Triglyceride levels in current drinkers ( 30698716)
  • Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Triglyceride levels x long total sleep time interaction (2df test) ( 31719535)
  • Triglycerides ( 24097068 25961943)
  • Type 2 diabetes ( 18372903 24509480 30054458 29358691 30297969)
  • Urate levels ( 31578528 23263486)
  • Urinary albumin-to-creatinine ratio ( 31630189)
  • Vascular endothelial growth factor levels ( 26910538 27989323 31217265)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in inactive individuals ( 28448500)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 25673412 28448500)
  • Waist-hip ratio ( 25673412 20935629)
  • Waist-to-hip ratio adjusted for BMI ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
  • Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
  • Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
  • Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
  • Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
  • Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
  • Waist-to-hip ratio adjusted for body mass index ( 26785701 25673412 28448500)
  • White blood cell count ( 27863252)
Interacting Genes 255 interacting genes: ABL1 ABL2 ADRB2 AKT1 ANKRD17 APEX1 APP AR ARRB1 ARRB2 ATF3 ATF4 ATM ATP2A2 ATRX AURKA BAIAP2L1 BRINP1 BTK BTRC CANX CASP2 CASP3 CCAR1 CCNG1 CDC34 CDH1 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CSNK2A1 CSNK2A2 CSNK2B CTBP2 CWC25 DAPK1 DAPK3 DAXX DDX24 DDX42 DHFR DLG4 DNAJB4 DYRK2 E2F1 EID1 EP300 ESR1 EZR F3 FBXO31 FHL2 FKBP1A FOXO1 G3BP2 GADD45A GCAT GLIS2 GNL3 GORAB GRK2 GSK3B GTF2E2 GYS2 H2BC21 H3-4 HCK HDAC1 HEY1 HIF1A HIPK2 HLA-DMB HMGA2 HMGN1 HNRNPK HSP90B1 IER3 IGF1R IRF1 IRF2 JMY JUN JUND KAT2B KAT5 KPNA1 LMO7 MAGEA2 MAP1LC3A MAP2 MAPKAPK2 MDM4 MED1 MKRN3 MS4A1 MTBP MYC MYD88 MYDGF NACA NAT10 NCL NGFR NOLC1 NOP53 NOTCH1 NPIPB3 NPM1 NR3C1 NUCKS1 NUMB PAK6 PBX1 PBXIP1 PDE4D PDIA3 PDLIM7 PDS5A PER2 PGAM2 PHF7 PHLDB3 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PPP1R10 PRDM2 PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RAD23A RANBP1 RANBP2 RARA RASSF1 RB1 RBBP6 RBM38 RCHY1 RESF1 RIDA RLIM RNF10 RNF126 RNF8 RPL11 RPL22 RPL26 RPL36A RPL4 RPL5 RPS23 RPS27A RPS3 RPS5 RRM2B RRP1 RSL1D1 RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SENP3 SESN2 SET SETD7 SETDB1 SHPK SIRT2 SIRT3 SMARCA2 SMARCA4 SMARCE1 SMG7 SORBS2 SRC SREK1 SRSF11 STK11 SUMO1 TAF1 TBP TCAP TERT TFIP11 TOP1 TP53 TP53I3 TP53RK TP73 TPR TPT1 TRAF5 TRIM13 TRIM23 TRIM27 TRIM4 TRIM9 TSG101 UBB UBC UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2J2 UBE2K UBE2L3 UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2Z UBE3A UBQLN4 UBTF USP15 USP2 USP7 VEGFA WRN WT1 XBP1 XIAP XPC YY1AP1 ZNF133 ZNF420 32 interacting genes: ADAMTS1 AKT1 CCN2 CRYAB ELAVL1 EPHB2 FLT1 FN1 GPC1 HIF1A HNRNPD IGFBP7 KDR LYVE1 MDM2 NRP1 NRP2 PGF PRRG4 SEMA3F SP1 SP3 SPARC TFAP2A TNXB U2AF1 UBIAD1 VEGFB VPS35 VTN YBX1 YBX3
Entrez ID 4193 7422
HPRD ID 01272 01889
Ensembl ID ENSG00000135679 ENSG00000112715
Uniprot IDs A0A0A8KB75 A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0 A0A024RD33 A0A024RD37 A0A0Y0IMM4 A2A2V4 P15692
PDB IDs 1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2MPS 2RUH 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3MQS 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4HG7 4JV7 4JV9 4JVE 4JVR 4JWR 4MDN 4MDQ 4OAS 4OBA 4OCC 4ODE 4ODF 4OGN 4OGT 4OGV 4OQ3 4QO4 4QOC 4UD7 4UE1 4UMN 4WT2 4XXB 4ZFI 4ZGK 4ZYC 4ZYF 4ZYI 5AFG 5C5A 5HMH 5HMI 5HMK 5J7F 5J7G 5LAV 5LAW 5LAY 5LAZ 5LN2 5MNJ 5OAI 5OC8 5SWK 5TRF 5UMM 5VK0 5WTS 5XXK 5Z02 5ZXF 6AAW 6GGN 6H22 6I29 6I3S 6IM9 6KZU 6Q96 6Q9H 6Q9L 6Q9O 1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS 4KZN 4QAF 4WPB 4ZFF 5DN2 5FV1 5FV2 5HHC 5HHD 5O4E 5T89 6BFT 6D3O
Enriched GO Terms of Interacting Partners?
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