MDH2 and NDUFS1

Number of citations of the paper that reports this interaction (PubMedID 6439716)
35

Data Source:
HPRD (in vitro)

		MDH2	NDUFS1
Description		malate dehydrogenase 2	NADH:ubiquinone oxidoreductase core subunit S1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome	Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Intermembrane Space Mitochondrial Matrix
	Molecular Function	RNA Binding L-malate Dehydrogenase Activity Protein Self-association Malate Dehydrogenase (NADP+) Activity	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process Internal Protein Amino Acid Acetylation NADH Metabolic Process Aerobic Respiration	Mitochondrial Electron Transport, NADH To Ubiquinone Apoptotic Mitochondrial Changes Mitochondrial Respiratory Chain Complex I Assembly Cellular Respiration ATP Metabolic Process Regulation Of Mitochondrial Membrane Potential Reactive Oxygen Species Metabolic Process
Pathways		Gluconeogenesis Citric acid cycle (TCA cycle)	Respiratory electron transport Complex I biogenesis
Drugs		NADH Citric Acid Xanthinol	NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Body mass index ( 26426971) Chronotype ( 30696823) Frontotemporal dementia with GRN mutation ( 29724592) Morning person ( 30696823)
Interacting Genes		8 interacting genes: CRYAB CS FH GOT2 HSPB1 NDUFS1 PC WARS1	3 interacting genes: CASP3 KDM1A MDH2
Entrez ID		4191	4719
HPRD ID		01099	01145
Ensembl ID		ENSG00000146701	ENSG00000023228
Uniprot IDs		A0A024R4K3 B3KTM1 G3XAL0 P40926	E5KRK5 P28331
PDB IDs		2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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