MC2R and POMC

Number of citations of the paper that reports this interaction (PubMedID 12213892)
14

Data Source:
HPRD (in vivo)

		MC2R	POMC
Description		melanocortin 2 receptor	proopiomelanocortin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Secretory Granule Lumen
	Molecular Function	Melanocortin Receptor Activity Corticotropin Receptor Activity Protein Binding	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Placenta Development G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway	Generation Of Precursor Metabolites And Energy Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Cytokine-mediated Signaling Pathway Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) ADORA2B mediated anti-inflammatory cytokines production	Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ADORA2B mediated anti-inflammatory cytokines production
Drugs		Tetracosactide Corticotropin	Loperamide Etorphine Dihydromorphine
Diseases		Adrenal carcinoma
GWAS		Negative urgency ( 30718321) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)	Body mass index ( 26426971 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 28552196 23563607 18391951) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)
Interacting Genes		2 interacting genes: ASIP POMC	12 interacting genes: APP FGF10 HLA-DRB3 MC1R MC2R MC3R MC4R MC5R MEP1A NRDC PAM VTN
Entrez ID		4158	5443
HPRD ID		06304	01462
Ensembl ID		ENSG00000185231	ENSG00000115138
Uniprot IDs		Q01718	P01189
PDB IDs			4XNH 4XPD 4Y49
Enriched GO Terms of Interacting Partners?
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