POMC and MC5R

Number of citations of the paper that reports this interaction (PubMedID 8185570)
54

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		POMC	MC5R
Description		proopiomelanocortin	melanocortin 5 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Secretory Granule Lumen	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	Melanocortin Receptor Activity Protein Binding Hormone Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Cytokine-mediated Signaling Pathway Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ADORA2B mediated anti-inflammatory cytokines production	Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Body mass index ( 26426971 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 28552196 23563607 18391951) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)	Depression in smokers ( 30219690) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		12 interacting genes: APP FGF10 HLA-DRB3 MC1R MC2R MC3R MC4R MC5R MEP1A NRDC PAM VTN	3 interacting genes: AGRP ASIP POMC
Entrez ID		5443	4161
HPRD ID		01462	08965
Ensembl ID		ENSG00000115138	ENSG00000176136
Uniprot IDs		P01189	P33032
PDB IDs		4XNH 4XPD 4Y49
Enriched GO Terms of Interacting Partners?
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