POMC and HLA-DRB3

Number of citations of the paper that reports this interaction (PubMedID 7477400)
118

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		POMC	HLA-DRB3
Description		proopiomelanocortin	major histocompatibility complex, class II, DR beta 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Secretory Granule Lumen	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Cytokine-mediated Signaling Pathway Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion	Adaptive Immune Response Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway
Pathways		Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ADORA2B mediated anti-inflammatory cytokines production	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs		Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Body mass index ( 26426971 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 28552196 23563607 18391951) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)	Plantar warts ( 28928442)
Interacting Genes		12 interacting genes: APP FGF10 HLA-DRB3 MC1R MC2R MC3R MC4R MC5R MEP1A NRDC PAM VTN	4 interacting genes: CDCA8 CTAG1B MAP3K13 POMC
Entrez ID		5443	3125
HPRD ID		01462	09985
Ensembl ID		ENSG00000115138
Uniprot IDs		P01189	A0A4D6G1L1 P79483
PDB IDs		4XNH 4XPD 4Y49	2Q6W 3C5J 4H1L
Enriched GO Terms of Interacting Partners?
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