MAL and EDA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MAL	EDA
Description		mal, T cell differentiation protein	ectodysplasin A
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Plasma Membrane Raft Membrane Raft Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane	Extracellular Region Collagen Trimer Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell
	Molecular Function	Protein Binding Lipid Binding Peptidase Activator Activity Involved In Apoptotic Process Structural Constituent Of Myelin Sheath	Signaling Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Membrane Raft Polarization Protein Localization To Paranode Region Of Axon Apoptotic Process Central Nervous System Development Cell Differentiation Myelination Apical Protein Localization Protein Insertion Into Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Immune Response Cell-matrix Adhesion Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways			TNFs bind their physiological receptors
Drugs
Diseases			Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS			Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		10 interacting genes: EDA FIBCD1 KLRC1 LDLRAD1 LMNA LSMEM1 MYD88 PTPRN SMIM3 USP7	15 interacting genes: ATP6V0C CYB561 DOLK EDA2R EDAR EMP3 FURIN GIMAP5 LEPROTL1 MAL NIPAL3 OSTC OSTCP1 PLN SEC22A
Entrez ID		4118	1896
HPRD ID		01789	02347
Ensembl ID		ENSG00000172005	ENSG00000158813
Uniprot IDs		A0A024RE19 P21145	A0A0U5J797 Q92838
PDB IDs			1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?
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