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SMAD1 and PSMB4
Number of citations of the paper that reports this interaction (PubMedID
15231748
)
85
Data Source:
HPRD
(two hybrid, in vivo)
SMAD1
PSMB4
Description
SMAD family member 1
proteasome 20S subunit beta 4
Image
GO Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Nuclear Inner Membrane
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Integral Component Of Membrane
Protein-containing Complex
SMAD Protein Complex
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Beta-subunit Complex
Extracellular Exosome
Molecular Function
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
DEAD/H-box RNA Helicase Binding
Protein Kinase Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Identical Protein Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
Primary MiRNA Binding
Lipopolysaccharide Binding
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Biological Process
MAPK Cascade
Ureteric Bud Development
Mesodermal Cell Fate Commitment
Osteoblast Fate Commitment
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Gamete Generation
Negative Regulation Of Cell Proliferation
Embryonic Pattern Specification
Positive Regulation Of Gene Expression
Protein Deubiquitination
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Primary MiRNA Processing
Homeostatic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Cartilage Development
Cardiac Muscle Cell Proliferation
Bone Development
SMAD Protein Signal Transduction
Positive Regulation Of Cartilage Development
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Sprouting Angiogenesis
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Protein Catabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Signaling by BMP
Ub-specific processing proteases
RUNX2 regulates bone development
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK - noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS
Lung function (FEV1) (
30061609
)
Midgestational cytokine/chemokine levels (maternal genetic effect) (
30134952
)
Panic disorder (
31712720
)
Response to cognitive-behavioural therapy in anxiety disorder (
26989097
)
Blood trace element (Cu levels) (
23720494
)
Body mass index (
26426971
)
Interacting Genes
142 interacting genes:
ACVR1
ACVRL1
AKR1B1
ANKRD27
AP2A2
APP
AR
ARHGEF6
ARL4D
BMPR1A
BTBD2
BTG2
CAMSAP1
CDK7
CDK9
CHMP3
CILK1
COL4A1
DACH1
DNMT3L
DVL1
ECSIT
EIF2AK4
ELP3
EP300
ERBIN
EWSR1
FBXL12
FBXO30
FHL5
FOXG1
FRZB
GDF6
GLI3
GMEB1
GSC
HBP1
HIPK2
HOXA13
HOXA5
HOXC8
HOXD13
ING2
INPP4A
IRF2BP1
KAT2B
KMT2D
LEF1
LEMD3
LMNA
MAP2K3
MAPK1
MAST4
MBD1
MECOM
MED6
MEN1
MGA
MRTFB
NAT9
NEDD4
NEDD9
NEUROG1
NKX3-2
NOTCH2
OAZ1
OAZ3
PAK1
PARD3
PIAS1
PIAS4
PIGQ
PLEKHB1
PREB
PSMB4
PSMD1
PSMD11
PUM1
RAB2B
RAB30
RAB34
RAB38
RAB3B
RAB6B
RAC2
RAN
RAP2A
RASD2
RASL12
RFX1
RHEBL1
RHOG
RPS27A
SF3B1
SKI
SKIL
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMARCE1
SMURF1
SMURF2
SNIP1
SNRNP70
SOX5
SQSTM1
SS18L1
STARD13
STK11
STUB1
SUV39H1
TCF20
TGFBR1
TNNT1
TOB1
TRIP6
TTF1
TTF2
UBA52
UBC
UBE2Z
UBXN1
USP45
VEPH1
WDR77
XPC
XPO1
YAP1
YY1
ZBTB44
ZDHHC3
ZEB2
ZNF251
ZNF423
ZNF510
ZNF512B
ZNF521
ZNF76
ZNF8
ZSCAN4
11 interacting genes:
APP
CUL1
FSD2
OAZ1
PLK1
PRKCA
PRPF19
PSMB5
PSMD2
PSMG3
SMAD1
Entrez ID
4086
5692
HPRD ID
03356
03710
Ensembl ID
ENSG00000170365
ENSG00000159377
Uniprot IDs
Q15797
A0A140VK46
P28070
PDB IDs
1KHU
2LAW
2LAX
2LAY
2LAZ
2LB0
2LB1
3Q47
3Q4A
5ZOK
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
Enriched GO Terms of Interacting Partners
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